Kidney disease is a global health crisis affecting more than 850 million people worldwide. In
the United States, annual Medicare expenditures for kidney disease and organ failure …

Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a large variety of
malformations that arise from defective kidney or urinary tract development and frequently …

Nephron progenitor cells (NPCs) self-renew and differentiate into nephrons, the functional
units of the kidney. Here, manipulation of p38 and YAP activity allowed for long-term clonal …

In humans born at term, maximal nephron number is reached by the time nephrogenesis is
completed—at approximately 36 weeks' gestation. The number of nephrons does not …

A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …

Preterm birth, defined as birth before the gestational age of 37 weeks, affects 11% of the
newborns worldwide. While extensive research has focused on the immediate complications …

Nephrons are the functional units which comprise the kidney. Each nephron contains a
number of physiologically unique populations of specialized epithelial cells that are …

Background The proximal tubule plays a major role in electrolyte homeostasis. Previous
studies have shown that HNF4A regulates reabsorption-related genes and promotes …

The mammalian kidney maintains fluid homeostasis through diverse epithelial cell types
generated from nephron and ureteric progenitor cells. To extend a developmental …

Acute kidney injury (AKI) is a common condition associated with significant morbidity,
mortality, and cost. Injured kidney tissue can regenerate after many forms of AKI. However …