The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …

Alzheimer's disease (AD) is behaviorally identified by progressive memory impairment and
pathologically characterized by the triad of β-amyloid plaques, neurofibrillary tangles, and …

Early Alzheimer's disease (AD) is associated with hippocampal hyperactivity and decreased
sleep quality. Here we show that homeostatic mechanisms transiently counteract the …

Since 1995, more than 100 transgenic (Tg) mouse models of Alzheimer's disease (AD) have
been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) …

Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …

Aging is associated with alterations in cognitive processing and brain neurophysiology.
Whereas the primary symptom of amnestic mild cognitive impairment (aMCI) is memory …

Patients with Alzheimer's disease (AD) suffer from spatial memory impairment and
wandering behavior, but the brain circuit mechanisms causing such symptoms remain …

Alzheimer's disease (AD) pathology is commonly associated with cognitive decline but is
also composed of neuropsychiatric symptoms including psychological distress and …

Sustained microglial activation and increased pro-inflammatory signalling cause chronic
inflammation and neuronal damage in Alzheimer's disease (AD). Resolution of inflammation …

Synaptic dysfunction is widely proposed as an initial insult leading to the neurodegeneration
observed in Alzheimer's disease (AD). We hypothesize that the initial insult originates in the …