Prefrontal cortical executive functions comprise a number of cognitive capabilities necessary
for goal directed behavior and adaptation to a changing environment. Executive dysfunction …

Stress-related substance use is a major challenge for treating substance use disorders. This
selective review focuses on emerging pharmacotherapies with potential for reducing stress …

Rationale The flashing lights and sounds of modern casinos are alluring and may contribute
to the addictive nature of gambling. Such cues can have a profound impact on the …

The selective α2A adrenoceptor agonist guanfacine reduces hyperactivity and improves
cognitive impairment in patients with attention-deficit/hyperactivity disorder (ADHD). The …

Lithium's efficacy in reducing both symptom severity in bipolar disorder (BD) and suicide risk
across clinical populations may reflect its ability to reduce impulsivity. Changes in immune …

Rationale Noradrenergic dysfunction is associated with disorders of impulsivity and
inattention. The rodent continuous performance test (rCPT) quantifies changes in attention …

Attention deficit hyperactivity disorder (ADHD) is manifested by a specific set of behavioral
deficits such as hyperactivity, impulsivity, and inattention. The dopamine neurotransmitter …

Neuropharmacological interventions in preclinical translational models of impulsivity have
tremendously contributed to a better understanding of the neurochemistry and neural basis …

Individuals might be exposed to intense acute stress while having to make decisions with far-
reaching consequences. Acute stress impairs processes required for decision-making by …

Rationale Chronic administration of D 2/3 receptor agonists ropinirole or pramipexole can
increase the choice of uncertain rewards in rats, theoretically approximating iatrogenic …