Dying cells have an important role in the initiation of CD8+ T cell-mediated immunity. The
cross-presentation of antigens derived from dying cells enables dendritic cells to present …

Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

The immune system is routinely exposed to dead cells during normal cell turnover, injury
and infection. Mechanisms must exist to discriminate between different forms of cell death to …

Dendritic cells (DCs) collect and process antigens for presentation to T cells, but there are
many variations on this basic theme. DCs differ in the regulatory signals they transmit …

Paraneoplastic Syndromes Involving the Nervous System | New England Journal of Medicine
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A common view supposes that dendritic cells (DCs) exist in two basic functional states:
immature DCs induce tolerance to self, whereas mature DCs induce immunity to foreign …

Phagosome maturation is the process by which internalized particles (such as bacteria and
apoptotic cells) are trafficked into a series of increasingly acidified membrane-bound …

Stimulation of naïve CD8+ T cells with antigen and costimulation results in proliferation and
weak clonal expansion, but the cells fail to develop effector functions and are tolerant long …

Pathogen invasion induces a rapid inflammatory response initiated through the recognition
of pathogen‐derived molecules by pattern recognition receptors (PRRs) expressed on both …

The mammalian immune system discriminates between modes of cell death; necrosis often
results in inflammation and adaptive immunity, whereas apoptosis tends to be anti …