Progesterone and estrogen signaling in the endometrium: what goes wrong in endometriosis?

RM Marquardt, TH Kim, JH Shin, JW Jeong - International journal of …, 2019 - mdpi.com
In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly
regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo …

Progesterone actions and resistance in gynecological disorders

JA MacLean, K Hayashi - Cells, 2022 - mdpi.com
Estrogen and progesterone and their signaling mechanisms are tightly regulated to maintain
a normal menstrual cycle and to support a successful pregnancy. The imbalance of estrogen …

Cyclic decidualization of the human endometrium in reproductive health and failure

B Gellersen, JJ Brosens - Endocrine reviews, 2014 - academic.oup.com
Decidualization denotes the transformation of endometrial stromal fibroblasts into
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …

Mechanisms of implantation: strategies for successful pregnancy

J Cha, X Sun, SK Dey - Nature medicine, 2012 - nature.com
Physiological and molecular processes initiated during implantation for pregnancy success
are complex but highly organized. This review primarily highlights adverse ripple effects …

Progesterone resistance in endometriosis: current evidence and putative mechanisms

P Zhang, G Wang - International journal of molecular sciences, 2023 - mdpi.com
Endometriosis is an estrogen-dependent disease characterized by the growth of
endometrial-like tissue outside the uterus. Progestins are currently the most commonly used …

Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries

GJ Martinez, M Appleton, ZA Kipp… - Physiological …, 2024 - journals.physiology.org
The normal stress response in humans is governed by the hypothalamic-pituitary-adrenal
(HPA) axis through heightened mechanisms during stress, raising blood levels of the …

Physiological and molecular determinants of embryo implantation

S Zhang, H Lin, S Kong, S Wang, H Wang… - Molecular aspects of …, 2013 - Elsevier
Embryo implantation involves the intimate interaction between an implantation-competent
blastocyst and a receptive uterus, which occurs in a limited time period known as the …

Genomic and epigenomic mechanisms of glucocorticoids in the brain

JD Gray, JF Kogan, J Marrocco… - Nature Reviews …, 2017 - nature.com
Following the discovery of glucocorticoid receptors in the hippocampus and other brain
regions, research has focused on understanding the effects of glucocorticoids in the brain …

Roadmap to embryo implantation: clues from mouse models

H Wang, SK Dey - Nature Reviews Genetics, 2006 - nature.com
Implantation involves an intricate discourse between the embryo and uterus and is a
gateway to further embryonic development. Synchronizing embryonic development until the …

Endometrial decidualization: of mice and men

CY Ramathal, IC Bagchi, RN Taylor… - Seminars in …, 2010 - thieme-connect.com
In murine and human pregnancies, embryos implant by attaching to the luminal epithelium
and invading into the stroma of the endometrium. Under the influence of the steroid …