The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …

Ever since the signal hypothesis was proposed in 1971, the exact nature of signal peptides
has been a focus point of research. The prediction of signal peptides and protein subcellular …

PIEZO2 is a mechanosensitive cation channel that has a key role in sensing touch, tactile
pain, breathing and blood pressure. Here we describe the cryo-electron microscopy …

Mechanosensitive ion channels convert external mechanical stimuli into electrochemical
signals for critical processes including touch sensation, balance, and cardiovascular …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

We describe and validate a new membrane protein topology prediction method, TMHMM,
based on a hidden Markov model. We present a detailed analysis of TMHMM's performance …

The fly Drosophila melanogaster is one of the most intensively studied organisms in biology
and serves as a model system for the investigation of many developmental and cellular …

A novel method to model and predict the location and orientation of alpha helices in
membrane-spanning proteins is presented. It is based on a hidden Markov model (HMM) …

An inherent problem in transmembrane protein topology prediction and signal peptide
prediction is the high similarity between the hydrophobic regions of a transmembrane helix …

The major facilitator superfamily (MFS) is one of the two largest families of membrane
transporters found on Earth. It is present ubiquitously in bacteria, archaea, and eukarya and …