Over the last 100–120 years, due to the ever-increasing importance of fluorine-containing
compounds in modern technology and daily life, the explosive development of the …

Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic
complications create a substantial burden on both the afflicted patients and society as a …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Diabetes mellitus, a disorder of metabolism, results in the elevation of glucose level in the
blood. In this hyperglycaemic condition, aldose reductase overexpresses and leads to …

Medicinal plants play a fundamental part in health sectors via the management of different
infectious diseases because of their wide plenitude wellspring of bioactive phytochemicals …

Diabetic neuropathy is one of the clinical syndromes characterized by pain and substantial
morbidity primarily due to a lesion of the somatosensory nervous system. The burden of …

Here we report biallelic mutations in the sorbitol dehydrogenase gene (SORD) as the most
frequent recessive form of hereditary neuropathy. We identified 45 individuals from 38 …