Translational research has revolutionized how we develop new treatments for cancer
patients. The change from an organ-centric concept guiding treatment choice towards deep …

Personal thermal comfort prediction modeling has become a trending topic in efforts to
improve individual indoor comfort, a notion that is closely related to the design and …

Background Women experience adverse drug reactions, ADRs, nearly twice as often as
men, yet the role of sex as a biological factor in the generation of ADRs is poorly understood …

Model-informed precision dosing (MIPD) has become synonymous with modern approaches
for individualizing drug therapy, in which the characteristics of each patient are considered …

The integration of artificial intelligence in precision medicine has revolutionized healthcare
delivery. Precision medicine identifies the phenotype of particular patients with less-common …

Model-informed precision dosing (MIPD) software tools are used to optimize dosage
regimens in individual patients, aiming to achieve drug exposure targets associated with …

Variability in individual capacity for hepatic elimination of therapeutic drugs is well
recognized and is associated with variable expression and activity of liver enzymes and …

The blood–brain barrier (BBB) maintains brain homeostasis by controlling traffic of
molecules from the circulation into the brain. This function is predominantly dependent on …

Sex differences in the lifetime risk and expression of disease are well-known. Preclinical
research targeted at improving treatment, increasing health span, and reducing the financial …

The administered dose of a drug modulates whether patients will experience optimal
effectiveness, toxicity including death, or no effect at all. Dosing is particularly important for …