Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke

J Montaner, L Ramiro, A Simats, S Tiedt… - Nature Reviews …, 2020 - nature.com
Despite many years of research, no biomarkers for stroke are available to use in clinical
practice. Progress in high-throughput technologies has provided new opportunities to …

Blood biomarkers for stroke diagnosis and management

J Kamtchum-Tatuene, GC Jickling - Neuromolecular medicine, 2019 - Springer
Biomarkers are objective indicators used to assess normal or pathological processes,
evaluate responses to treatment and predict outcomes. Many blood biomarkers already …

Predictors of futile recanalization after endovascular treatment in acute ischemic stroke: a meta-analysis

G Deng, J **ao, H Yu, M Chen, K Shang… - Journal of …, 2022 - jnis.bmj.com
Background Despite successful recanalization after endovascular treatment, many patients
with acute ischemic stroke due to large vessel occlusion still show functional dependence …

The role of plasminogen activators in stroke treatment: fibrinolysis and beyond

AM Thiebaut, M Gauberti, C Ali… - The Lancet …, 2018 - thelancet.com
Although recent technical advances in thrombectomy have revolutionised acute stroke
treatment, prevalence of disability and death related to stroke remain high. Therefore …

Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome

RC Nogueira, M Aries, JS Minhas… - Journal of Cerebral …, 2022 - journals.sagepub.com
Acute stroke is associated with high morbidity and mortality. In the last decades, new
therapies have been investigated with the aim of improving clinical outcomes in the acute …

Biomarkers of unfavorable outcome in acute ischemic stroke patients with successful recanalization by endovascular thrombectomy

N Zang, Z Lin, K Huang, Y Pan, Y Wu, Y Wu… - Cerebrovascular …, 2020 - karger.com
Background: We aimed to identify plasma markers of unfavorable outcomes for patients with
acute ischemic stroke (AIS) after recanalization by endovascular thrombectomy (EVT) …

Thrombus heterogeneity in ischemic stroke

S Staessens, SF De Meyer - Platelets, 2021 - Taylor & Francis
The structure of stroke thrombi has gained an increasing amount of interest in recent years.
The advent of endovascular thrombectomy has offered the unique opportunity to provide …

Composition and organization of acute ischemic stroke thrombus: a wealth of information for future thrombolytic strategies

JP Desilles, L Di Meglio, F Delvoye, B Maïer… - Frontiers in …, 2022 - frontiersin.org
During the last decade, significant progress has been made in understanding thrombus
composition and organization in the setting of acute ischemic stroke (AIS). In particular …

Association of interleukin-6 levels and futile reperfusion after mechanical thrombectomy

L Mechtouff, T Bochaton, A Paccalet, CC Da Silva… - Neurology, 2021 - AAN Enterprises
Objective To assess whether interleukin-6 (IL-6) level is a marker of futile reperfusion in
patients with acute ischemic stroke (AIS) with large vessel occlusion treated with mechanical …

Plasma lipid mediators associate with clinical outcome after successful endovascular thrombectomy in patients with acute ischemic stroke

J Hao, Y Feng, X Xu, L Li, K Yang, G Dai… - Frontiers in …, 2022 - frontiersin.org
Background Neuroinflammatory response contributes to early neurological deterioration
(END) and unfavorable long-term functional outcome in patients with acute ischemic stroke …