Human papillomavirus genomics: Understanding carcinogenicity

CW Nelson, L Mirabello - Tumour virus research, 2023 - Elsevier
Human papillomavirus (HPV) causes virtually all cervical cancers and many cancers at other
anatomical sites in both men and women. However, only 12 of 448 known HPV types are …

Papillomavirus immune evasion strategies target the infected cell and the local immune system

C Zhou, ZK Tuong, IH Frazer - Frontiers in oncology, 2019 - frontiersin.org
Persistent infection with human papillomavirus (HPV) initiates~ 5% of all human cancers,
and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection …

Cervicovaginal microbiome and natural history of HPV in a longitudinal study

M Usyk, CP Zolnik, PE Castle, C Porras… - PLoS …, 2020 - journals.plos.org
Background Human papillomavirus (HPV) infection is one of the most common sexually
transmitted infections. However, only a small percentage of high-risk (HR) HPV infections …

APOBEC: A molecular driver in cervical cancer pathogenesis

S Revathidevi, AK Murugan, H Nakaoka, I Inoue… - Cancer letters, 2021 - Elsevier
Cervical cancer is one of the foremost common cancers in women. Human papillomavirus
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …

Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study

SJ Bowden, B Bodinier, I Kalliala, V Zuber… - The Lancet …, 2021 - thelancet.com
Background Most uterine cervical high-risk human papillomavirus (HPV) infections are
transient, with only a small fraction develo** into cervical cancer. Family aggregation …

Human Oncogenic Viruses: Characteristics and Prevention Strategies—Lessons Learned from Human Papillomaviruses

L Galati, MV Chiantore, M Marinaro, P Di Bonito - Viruses, 2024 - mdpi.com
Approximately 12% of human cancers worldwide are associated with infectious agents,
which are classified by the International Agency for Research on Cancer (IARC) as Group 1 …

Genomic risk factors for cervical cancer

D Ramachandran, T Dörk - Cancers, 2021 - mdpi.com
Simple Summary Cervical cancer is the fourth leading cause of cancer-related deaths in
females worldwide. Despite an active immunisation strategy in many countries, high-risk …

Cancer PRSweb: an online repository with polygenic risk scores for major cancer traits and their evaluation in two independent biobanks

LG Fritsche, S Patil, LJ Beesley, P VandeHaar… - The American Journal of …, 2020 - cell.com
To facilitate scientific collaboration on polygenic risk scores (PRSs) research, we created an
extensive PRS online repository for 35 common cancer traits integrating freely available …

GWAS meta-analyses clarify the genetics of cervical phenotypes and inform risk stratification for cervical cancer

M Koel, U Võsa, M Jõeloo, K Läll… - Human Molecular …, 2023 - academic.oup.com
Genome-wide association studies (GWAS) have successfully identified associations for
cervical cancer, but the underlying mechanisms of cervical biology and pathology remain …

Global inequities in precision medicine and molecular cancer research

TM Drake, SR Knight, EM Harrison, K Søreide - Frontiers in Oncology, 2018 - frontiersin.org
Precision medicine based upon molecular testing is heralded as a revolution in how cancer
is prevented, diagnosed, and treated. Large efforts across the world aim to conduct …