Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Chemotherapy remains the most important means of controlling malaria, one of the
deadliest infectious parasitic diseases in the world. Antimalarial antifolates have been …

Malarial dihydrofolate reductase (DHFR) is the target of antifolate antimalarial drugs such as
pyrimethamine and cycloguanil, the clinical efficacy of which have been compromised by …

Tetrahydrofolate cofactors are essential for the synthesis of purines, certain amino acids,
and thymidine. Most bacteria and plants produce these folate cofactors by de novo …

Among all heterocycles, the triazine scaffold occupies a prominent position, possessing a
broad range of biological activities. Triazine is found in many potent biologically active …

Malaria is a leading cause of morbidity and mortality in the tropics. Chemotherapeutic and
vector control strategies have been applied for more than a century but have not been …

Malaria is one of the most prevalent and devastating infectious diseases of our time. Yet,
unfortunately, apart from artemisinin combination therapies there are relatively few effective …

Pyrimidine ring is the building unit of DNA and RNA and thus pyrimidine based chemical
architectures exhibit diverse pharmacological activities. Among the reported medicinal …

Human epidermal growth factor receptor 2 (HER2) is a member of epidermal growth factor
receptors with tyrosine kinase functionality. The dimerization of HER2 leads to the …

Parasitic apicomplexans are responsible for some of the most severe worldwide health
problems, including malaria, toxoplasmosis and cryptosporidiosis. These parasites are …