The identification of MPTP, a relatively simple compound which causes selective
degeneration of the substantia nigra after systemic administration, has had an a significant …

Neuroinflammation is one of the host defensive mechanisms through which the nervous
system protects itself from pathogenic and or infectious insults. Moreover, neuroinflammation …

Dopaminergic neurons of the substantia nigra are particularly vulnerable to oxidative and
inflammatory attack. Such processes may play a crucial role in the etiology of Parkinson …

Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by the
progressive loss of dopaminergic neurons in the substantia nigra and depletion of dopamine …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by a
selective loss of dopaminergic neurons in the substantia nigra (SN). It has been suggested …

Parkinson's disease (PD) is the second most common neurodegenerative disease
characterized by a progressive loss of dopamine (DA) neurons in the substantia nigra …

Significant evidence has now been accumulated that microglial cells play a central role in
the degeneration of DA neurons in animal models of PD. The oxidative stress response by …

Dextromethorphan (DM) is a commonly used antitussive and is currently the only FDA-
approved pharmaceutical treatment for pseudobulbar affect. Its safety profile and diverse …

Parkinson's disease (PD) is one of the most common neurodegenerative diseases
characterized with a gradual loss of midbrain substantia nigra (SN) dopamine (DA) neurons …

Neuroinflammation is closely associated with the pathogenesis of Parkinson's disease (PD)
and other neurological disorders. Increasing evidence suggests that inhibition of microglia …