Myocardial infarction triggers an intense inflammatory response that is essential for cardiac
repair, but which is also implicated in the pathogenesis of postinfarction remodelling and …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Resolution of inflammation is a coordinated and active process aimed at restoration of tissue
integrity and function. This review integrates the key molecular and cellular mechanisms of …

Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …

Macrophages are ubiquitous cells that reside in all major tissues. Counter to long-held
beliefs, we now know that resident macrophages in many organs are seeded during …

Myocardial infarction is defined as sudden ischemic death of myocardial tissue. In the
clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary …

Reperfusion therapy is widely used to treat acute myocardial infarction. However, its efficacy
is limited by myocardial ischemia-reperfusion injury (MIRI), which occurs paradoxically due …

Optimal healing of damaged tissue following myocardial infarction (MI) requires a
coordinated cellular response that can be divided into three phases: inflammatory …

Rationale: After myocardial infarction, neutrophils rapidly and massively infiltrate the heart,
where they promote both tissue healing and damage. Objective: To characterize the …

Chemokines and their receptors are key mediators of the inflammatory process regulating
leukocyte extravasation and directional migration into inflamed and infected tissues. The …