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[HTML][HTML] Beyond ATM: the protein kinase landscape of the DNA damage response
The DNA of all organisms is constantly subjected to damaging agents, both exogenous and
endogenous. One extremely harmful lesion is the double-strand break (DSB), which …
endogenous. One extremely harmful lesion is the double-strand break (DSB), which …
How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex
The telomerase enzyme, which synthesizes telomeric DNA repeats, is regulated in cis at
individual chromosome ends by the telomeric protein/DNA complex in a manner dependent …
individual chromosome ends by the telomeric protein/DNA complex in a manner dependent …
[HTML][HTML] CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability
TEL2 interacts with and is essential for the stability of all phosphatidylinositol 3-kinase-
related kinases (PIKKs), but its mechanism of action remains unclear. Here, we show that …
related kinases (PIKKs), but its mechanism of action remains unclear. Here, we show that …
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
H Takai, Y ** of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
To maintain genome integrity, cells must accurately duplicate their genome and repair DNA
lesions when they occur. To uncover genes that suppress DNA damage in human cells, we …
lesions when they occur. To uncover genes that suppress DNA damage in human cells, we …
ATM protein kinase: the linchpin of cellular defenses to stress
ATM is the most significant molecule involved in monitoring the genomic integrity of the cell.
Any damage done to DNA relentlessly challenges the cellular machinery involved in …
Any damage done to DNA relentlessly challenges the cellular machinery involved in …
[HTML][HTML] Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression
Elongation of telomeres by telomerase replenishes the loss of terminal telomeric DNA
repeats during each cell cycle. In budding yeast, Cdc13 plays an essential role in telomere …
repeats during each cell cycle. In budding yeast, Cdc13 plays an essential role in telomere …
[HTML][HTML] The role of Hsp90-R2TP in macromolecular complex assembly and stabilization
Hsp90 is a ubiquitous molecular chaperone involved in many cell signaling pathways, and
its interactions with specific chaperones and cochaperones determines which client proteins …
its interactions with specific chaperones and cochaperones determines which client proteins …
Branching the Tel2 pathway for exact fit on phosphatidylinositol 3-kinase-related kinases
Abstract Phosphatidylinositol 3-kinase-related kinases (PIKKs), are structurally related to
phosphatidylinositol 3-kinase (lipid kinase), but possess protein kinase activities. PIKKs …
phosphatidylinositol 3-kinase (lipid kinase), but possess protein kinase activities. PIKKs …