Opioid use disorder
Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …
Sex differences in neural mechanisms mediating reward and addiction
There is increasing evidence in humans and laboratory animals for biologically based sex
differences in every phase of drug addiction: acute reinforcing effects, transition from …
differences in every phase of drug addiction: acute reinforcing effects, transition from …
The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis
The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
Mu opioids and their receptors: evolution of a concept
Opiates are among the oldest medications available to manage a number of medical
problems. Although pain is the current focus, early use initially focused upon the treatment of …
problems. Although pain is the current focus, early use initially focused upon the treatment of …
Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature
Background Despite initial reports of a decline in use in the early 2000s, methamphetamine
remains a significant public health concern with known neurotoxic and neurocognitive …
remains a significant public health concern with known neurotoxic and neurocognitive …
The kappa opioid receptor: a promising therapeutic target for multiple pathologies
Kappa-opioid receptors (KOR) are widely expressed throughout the central nervous system,
where they modulate a range of physiological processes depending on their location …
where they modulate a range of physiological processes depending on their location …
[HTML][HTML] Prolactin: structure, function, and regulation of secretion
ME Freeman, B Kanyicska, A Lerant… - Physiological …, 2000 - journals.physiology.org
Prolactin is a protein hormone of the anterior pituitary gland that was originally named for its
ability to promote lactation in response to the suckling stimulus of hungry young mammals …
ability to promote lactation in response to the suckling stimulus of hungry young mammals …
Descending control of pain
MJ Millan - Progress in neurobiology, 2002 - Elsevier
Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …
information from the viscera, skin and other organs is subject to extensive processing by a …
[HTML][HTML] Reward processing by the opioid system in the brain
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by
endogenous opioid peptides processed from three protein precursors, proopiomelanocortin …
endogenous opioid peptides processed from three protein precursors, proopiomelanocortin …
Nicotine gateway effects on adolescent substance use
Given the rise in teenage use of electronic nicotine delivery systems (“va**”) in
congruence with the increasing numbers of drug-related emergencies, it is critical to expand …
congruence with the increasing numbers of drug-related emergencies, it is critical to expand …