▪ Abstract For 600 million years, the two best-understood metazoan species, the nematode
Caenorhabditis elegans and the fruit fly Drosophila melanogaster, have developed …

A versatile genetic method for identifying and cloning Drosophila melanogaster genes
affecting any recognizable phenotype is described. Strains are constructed in which the …

A single P element insert in Drosophila melanogaster, called P [ry+ delta 2-3](99B), is
described that caused mobilization of other elements at unusually high frequencies, yet is …

Drosophila offers many advantages as an experimental organism. However, in comparison
with yeast and mouse, two other widely used eukaryotic model systems, Drosophila suffers …

The switch gene, Sex-lethal (Sxl), controls sexual development and dosage compensation. It
must be active in females and inactive in males throughout development. Analysis of Sxl …

P transposable elements in Drosophila melanogaster can undergo precise loss at a rate
exceeding 13% per generation. The process is similar to gene conversion in its requirement …

The discovery that the primary transcripts of many genes are processed to produce more
than one kind of messenger RNA focuses attention on the control of RNA processing as a …

Sex-lethal Is a binary switch gene that controls all aspects of Drosophlla sexual dimorphism.
It must be active in females and inactive In males. The on/off regulation reflects alternative …

Transposable elements of the P family in Drosophila are thought to transpose by a cut-and-
paste process that leaves a double-strand gap. The repair of such gaps resulted in the …

The 'dominant female-sterile'technique used to generate germ-line mosaics in Drosophila is
a powerful tool to determine the tissue specificity (germ line versus somatic) of recessive …