The structural basis of herpesvirus entry

SA Connolly, TS Jardetzky, R Longnecker - Nature Reviews …, 2021 - nature.com
Herpesviruses are ubiquitous, double-stranded DNA, enveloped viruses that establish
lifelong infections and cause a range of diseases. Entry into host cells requires binding of …

Geographical distribution and pathogenesis of ticks and tick-borne viral diseases

T Shah, Q Li, B Wang, Z Baloch, X **a - Frontiers in microbiology, 2023 - frontiersin.org
Ticks are obligatory hematophagous arthropods that harbor and transmit infectious
pathogens to humans and animals. Tick species belonging to Amblyomma, Ixodes …

[HTML][HTML] Pseudorabies virus: from pathogenesis to prevention strategies

HH Zheng, PF Fu, HY Chen, ZY Wang - Viruses, 2022 - mdpi.com
Pseudorabies (PR), also called Aujeszky's disease (AD), is a highly infectious viral disease
which is caused by pseudorabies virus (PRV). It has been nearly 200 years since the first PR …

Targeted mutagenesis of the herpesvirus fusogen central helix captures transition states

M Zhou, B Vollmer, E Machala, M Chen… - Nature …, 2023 - nature.com
Herpesviruses remain a burden for animal and human health, including the medically
important varicella-zoster virus (VZV). Membrane fusion mediated by conserved core …

Assessment of the CASP14 assembly predictions

B Ozden, A Kryshtafovych… - … : Structure, Function, and …, 2021 - Wiley Online Library
In CASP14, 39 research groups submitted more than 2500 3D models on 22 protein
complexes. In general, the community performed well in predicting the fold of the assemblies …

Neuropilin-1 facilitates pseudorabies virus replication and viral glycoprotein B promotes its degradation in a furin-dependent manner

M Chen, MH Wang, XG Shen, H Liu, YY Zhang… - Journal of …, 2022 - journals.asm.org
Pseudorabies virus (PRV), which is extremely infectious and can infect numerous mammals,
has a risk of spillover into humans. Virus–host interactions determine viral entry and …

Current problems and future avenues in proteoliposome research

AM Amati, S Graf, S Deutschmann… - Biochemical Society …, 2020 - portlandpress.com
Membrane proteins (MPs) are the gatekeepers between different biological compartments
separated by lipid bilayers. Being receptors, channels, transporters, or primary pumps, they …

Membrane fusion, potential threats, and natural antiviral drugs of pseudorabies virus

N Ye, W Feng, T Fu, D Tang, Z Zeng, B Wang - Veterinary Research, 2023 - Springer
Pseudorabies virus (PrV) can infect several animals and causes severe economic losses in
the swine industry. Recently, human encephalitis or endophthalmitis caused by PrV infection …

Herpes simplex virus 1 entry glycoproteins form complexes before and during membrane fusion

Z Pataki, A Rebolledo Viveros, EE Heldwein - MBio, 2022 - journals.asm.org
Herpesviruses—ubiquitous pathogens that cause persistent infections—have some of the
most complex cell entry mechanisms. Entry of the prototypical herpes simplex virus 1 (HSV …

[HTML][HTML] Emodin as an inhibitor of PRV infection in vitro and in vivo

X Cai, Z Wang, X Li, J Zhang, Z Ren, Y Shao, Y Xu… - Molecules, 2023 - mdpi.com
Pseudorabies (PR) is an acute and severe infectious disease caused by pseudorabies virus
(PRV). Once the virus infects pigs, it is difficult to eliminate, resulting in major economic …