Betulin and betulinic acid: Triterpenoids derivatives with a powerful biological potential

A Hordyjewska, A Ostapiuk, A Horecka… - Phytochemistry …, 2019 - Springer
Betulin, a pentacyclic triterpene and a plant pentacyclic triterpene metabolite, can be found
in large quantities in the outer bark of the birches (Betula, Betulaceae). Betulinic acid …

Pharmacological activities of natural triterpenoids and their therapeutic implications

P Dzubak, M Hajduch, D Vydra, A Hustova… - Natural product …, 2006 - pubs.rsc.org
Covering: 1990–2005. Previous review: Nat. Prod. Rep., 2005, 22, 487 This article reviews
the pharmacological activity of naturally occurring triterpenoids excluding the degraded …

[PDF][PDF] Biological activities of lupeol

MBC Gallo, MJ Sarachine - Int. J. Biomed. Pharm. Sci, 2009 - globalsciencebooks.info
This review covers mainly the past 25 years of research on the biological activities of lupeol,
a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms …

Betulinic acid and its derivatives as potential antitumor agents

DM Zhang, HG Xu, L Wang, YJ Li… - Medicinal research …, 2015 - Wiley Online Library
Betulinic acid (BA) is a lupane‐type pentacyclic triterpene, distributed ubiquitously
throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities …

Inhibition of PINK1/Parkin-dependent mitophagy sensitizes multidrug-resistant cancer cells to B5G1, a new betulinic acid analog

N Yao, C Wang, N Hu, Y Li, M Liu, Y Lei, M Chen… - Cell Death & …, 2019 - nature.com
Betulinic acid (BA) and its derivatives are a class of high-profile drug candidates, but their
anticancer effects on resistant cancer have rarely been reported. Although a few studies …

Betulinic acid: recent advances in chemical modifications, effective delivery, and molecular mechanisms of a promising anticancer therapy

M Ali‐Seyed, I Jantan, K Vijayaraghavan… - Chemical biology & …, 2016 - Wiley Online Library
An important method of drug discovery is examination of diverse life forms, including
medicinal plants and natural products or bioactive compounds isolated from these sources …

Rearrangement of N-Oxyenamines and Related Reactions

AA Tabolin, SL Ioffe - Chemical Reviews, 2014 - ACS Publications
Hydroxylamines and their derivatives have found a wide range of applications in organic
synthesis. 1 In this review we hope to cover the synthetic applications of N …

Pentacyclic triterpenoids with nitrogen-and sulfur-containing heterocycles: synthesis and medicinal significance

M Kvasnica, M Urban, NJ Dickinson, J Sarek - Natural product reports, 2015 - pubs.rsc.org
Covering: 1962 to 2014 Triterpenoids are natural compounds with a variety of biological
activities and are usually produced by plants as secondary metabolites. In recent decades …

Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents

RY Kuo, K Qian, SL Morris-Natschke, KH Lee - Natural product reports, 2009 - pubs.rsc.org
Covering: January 2006 to December 2008 This article reviews the antitumor and anti-HIV
activities of naturally occurring triterpenoids, including the lupane, ursane, oleanane …

Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity

RC Santos, JAR Salvador, S Marín… - Bioorganic & medicinal …, 2009 - Elsevier
A series of new imidazole carboxylic esters (carbamates) and N-acylimidazole derivatives of
betulin and betulinic acid (14–29) have been synthesized. The new compounds were …