Rapid and accurate detection is a prerequisite for precise clinical diagnostics, ensuring food
safety, and facilitating biotechnological applications. The Argonaute system, as a cutting …

Abstract CRISPR/Cas and Argonaute (Ago) proteins, which target specific nucleic acid
sequences, can be applied as diagnostic tools. Despite high specificity and efficiency …

The evolution of hypervirulent and carbapenem-resistant Klebsiella pneumoniae can be
categorized into three main patterns: the evolution of KL1/KL2-hvKp strains into CR-hvKp …

With the attributes of high sensitivity, single-base resolution, multiplex detection capability,
and programmability upon nucleic acid recognition, Argonaute (Ago)-based biosensing …

Argonaute proteins (Agos) have emerged as key tools in molecular diagnosis because of
their ability to precisely target specific bases and perform multi-target cleavage. Previous …

In an era where swift and precise diagnostic capabilities are paramount, we introduce
NAPTUNE (Nucleic acids and Protein Biomarkers Testing via Ultra-sensitive Nucleases …

Molecular diagnostic technologies empower new clinical opportunities in precision
medicine. However, existing approaches face limitations with respect to performance …

Development of a multiplexed and sensitive biosensing platform is a priority for public health
security. We report a micropore resistance counting platform based on polystyrene …

As a class of emerging programmable endonucleases, prokaryotic Argonaute (pAgo) has
attracted much attention in biotechnology. In recent years, benefiting from their stability and …

Due to the notable biological advantages, programmable nucleases have become a
groundbreaking class of tools in the field of nucleic acid testing (NAT). Prokaryotic …