The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …

Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Microglia become progressively activated and seemingly dysfunctional with age, and
genetic studies have linked these cells to the pathogenesis of a growing number of …

Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Intracellular lipid droplets (LDs) are found in a wide variety of cell types and have been
recognized as organelles with unique spherical structures. Although LDs are not stable lipid …

Immune responses occur in the midst of a variety of cellular stresses that can severely
perturb endoplasmic reticulum (ER) function. The unfolded protein response is a three …

Neuroinflammation caused by microglial activation and consequent neurological impairment
are prominent features of diabetes-associated cognitive impairment (DACI). Microglial …

Adipose tissue plays a significant role in whole body energy homeostasis. Obesity‐
associated diabetes, fatty liver and metabolic syndrome are closely linked to adipose stress …

During the past decade, there has been a paradigm shift in our understanding of the roles of
intracellular lipid droplets (LDs). New genetic, biochemical and imaging technologies have …

Lipid droplets (LDs) were initially described as fat storage organelles in adipocytes, but are
increasingly recognized as dynamic players in lipid metabolism, with important roles not …