Endolysins are enzymes used by bacteriophages at the end of their replication cycle to
degrade the peptidoglycan of the bacterial host from within, resulting in cell lysis and release …

Peptidoglycan (PG) is the major structural component of the bacterial cell wall. Bacteria have
autolytic PG hydrolases that allow the cell to grow and divide. A well-studied group of PG …

Staphylococcus aureus is one of the most common pathogens of humans and animals,
where it frequently colonizes skin and mucosal membranes. It is of major clinical importance …

The emergence of bacteria resistance to most of the currently available antibiotics has
become a critical therapeutic problem. The bacteria causing both hospital and community …

Antibiotics have the remarkable power to control bacterial infections. Unfortunately,
widespread use, whether regarded as prudent or not, has favored the emergence and …

Endolysins and their derivatives have emerged in recent years as a novel class of
antibacterials, which have now entered the clinical phases. Their rapid mode-of-action and …

Antibiotics have had a profound impact on human society by enabling the eradication of
otherwise deadly infections. Unfortunately, antibiotic use and overuse has led to the rapid …

Lytic enzymes encoded by bacteriophages have been intensively explored as alternative
agents for combating bacterial pathogens in different contexts. The antibacterial character of …

The bactericidal activity of bacteriophages has been used to treat human infections for years
as an alternative or a complement to antibiotic therapy. Nowadays, endolysins (phage …

With the increasing worldwide prevalence of antibiotic resistant bacteria, bacteriophage
endolysins (lysins) represent a very promising novel alternative class of antibacterial in the …