Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

AMPK is a highly conserved master regulator of metabolism, which restores energy balance
during metabolic stress both at the cellular and physiological levels. The identification of …

Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …

AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …

Metformin is a first-line drug for the treatment of individuals with type 2 diabetes, yet its
precise mechanism of action remains unclear. Metformin exerts its antihyperglycemic action …

Mitochondria form a complex, interconnected reticulum that is maintained through
coordination among biogenesis, dynamic fission, and fusion and mitophagy, which are …

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy and nutrient status,
expressed almost universally in eukaryotes as heterotrimeric complexes comprising catalytic …

The AMP-activated protein kinase (AMPK) is a sensor of energy status that, when activated
by metabolic stress, maintains cellular energy homeostasis by switching on catabolic …

Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a heterotrimeric αβγ
complex that functions as a central regulator of energy homeostasis. Energy stress manifests …

Obesity is now a widespread disorder, and its prevalence has become a critical concern
worldwide, due to its association with common co-morbidities like cancer, cardiovascular …