Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies
and recombinant proteins, poses substantial challenges owing to their large size and …
and recombinant proteins, poses substantial challenges owing to their large size and …
The discovery and development of liraglutide and semaglutide
LB Knudsen, J Lau - Frontiers in endocrinology, 2019 - frontiersin.org
The discovery of glucagon-like peptide-1 (GLP-1), an incretin hormone with important effects
on glycemic control and body weight regulation, led to efforts to extend its half-life and make …
on glycemic control and body weight regulation, led to efforts to extend its half-life and make …
The therapeutic age of the neonatal Fc receptor
IgGs are essential soluble components of the adaptive immune response that evolved to
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …
The neonatal Fc receptor (FcRn): a misnomer?
Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …
(IgG) is the most common type of antibody found in circulation and extracellular fluids …
Albumin-based drug delivery: harnessing nature to cure disease
MT Larsen, M Kuhlmann, ML Hvam… - Molecular and cellular …, 2016 - Springer
The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic
levels, however, challenges such as rapid renal clearance, degradation or non-specific …
levels, however, challenges such as rapid renal clearance, degradation or non-specific …
Unraveling the mysteries of serum albumin—more than just a serum protein
Serum albumin is a multi-functional protein that is able to bind and transport numerous
endogenous and exogenous compounds. The development of albumin drug carriers is …
endogenous and exogenous compounds. The development of albumin drug carriers is …
Future directions for peptide therapeutics development
AA Kaspar, JM Reichert - Drug discovery today, 2013 - Elsevier
Highlights•An unprecedented number of peptide therapeutics have recently been
approved.•Clinical pipeline analysis reveals an emphasis on peptides with enhanced …
approved.•Clinical pipeline analysis reveals an emphasis on peptides with enhanced …
Hyaluronic acid and albumin based nanoparticles for drug delivery
C Lei, XR Liu, QB Chen, Y Li, JL Zhou, LY Zhou… - Journal of Controlled …, 2021 - Elsevier
Albumin, a multifunctional protein, is widely used to prepare nanocarriers. Hyaluronic acid
(HA) is a natural glycosaminoglycan that can specifically bind receptors, such as cluster of …
(HA) is a natural glycosaminoglycan that can specifically bind receptors, such as cluster of …
[HTML][HTML] Biomacromolecules as carriers in drug delivery and tissue engineering
Y Zhang, T Sun, C Jiang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
Natural biomacromolecules have attracted increased attention as carriers in biomedicine in
recent years because of their inherent biochemical and biophysical properties including …
recent years because of their inherent biochemical and biophysical properties including …
Albumin as a versatile platform for drug half-life extension
Background Albumin is the most abundant plasma protein, is highly soluble, very stable and
has an extraordinarily long circulatory half-life as a direct result of its size and interaction …
has an extraordinarily long circulatory half-life as a direct result of its size and interaction …