Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection
and population expansion. Early steps in this process are driven by a set of mutated driver …

Although researchers have identified genetic alterations that contribute to development of
esophageal adenocarcinoma, we know little about features of patients or environmental …

There is a dearth of knowledge about the pathogenesis of premalignant lung lesions,
especially for atypical adenomatous hyperplasia (AAH), the only known precursor for the …

Throughout the evolution of the definition of Barrett's esophagus (BE), the one thing that has
remained constant is the identification of some form of columnar epithelium on histologic …

Oesophageal cancer (OC) is an inflammation-associated malignancy linked to gastro-
oesophageal reflux disease, obesity and tobacco use. Knowledge of the microenvironment …

Oesophageal adenocarcinoma (OAC) is an aggressive malignancy with poor prognosis,
and incidence is increasing rapidly in the Western world. Mucosal-associated invariant T …

Cytokines are signalling proteins generated in most part by immune cells that have critical
functions in cellular lifespan. here we present recent data on three selected anti …

The association between vitamin D and cancer has long been studied, but the results have
been variable. Thus, there does not seem to be a consensus on whether vitamin D has a …

Gut inflammation has been correlated with cancerogenesis by disrupting gastrointestinal
homeostasis. Numerous chronic inflammatory disorders of the tubular gastrointestinal tract …

Cancer development is a dynamic evolutionary process characterized by marked
intratumoural heterogeneity at the genetic, epigenetic and phenotypic levels. Barrett …