Retinoids, retinoic acid receptors, and cancer
Retinoids (ie, vitamin A, all-trans retinoic acid, and related signaling molecules) induce the
differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but …
differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but …
Retinoic acid receptors: from molecular mechanisms to cancer therapy
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
RAR and RXR modulation in cancer and metabolic disease
Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as
heterodimers with retinoid X receptors (RXRs) to regulate cell growth and survival. The …
heterodimers with retinoid X receptors (RXRs) to regulate cell growth and survival. The …
Retinoid pathway and cancer therapeutics
N Bushue, YJY Wan - Advanced drug delivery reviews, 2010 - Elsevier
The retinoids are a class of compounds that are structurally related to vitamin A. Retinoic
acid, which is the active metabolite of retinol, regulates a wide range of biological processes …
acid, which is the active metabolite of retinol, regulates a wide range of biological processes …
PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3
M Jeanne, V Lallemand-Breitenbach, O Ferhi, M Koken… - Cancer cell, 2010 - cell.com
As 2 O 3 cures acute promyelocytic leukemia (APL) by initiating PML/RARA oncoprotein
degradation, through sumoylation of its PML moiety. However, how As 2 O 3 initiates PML …
degradation, through sumoylation of its PML moiety. However, how As 2 O 3 initiates PML …
Acute promyelocytic leukaemia: novel insights into the mechanisms of cure
H de Thé, Z Chen - Nature Reviews Cancer, 2010 - nature.com
The fusion oncogene, promyelocytic leukaemia (PML)–retinoic acid receptor-α (RARA),
initiates acute promyelocytic leukaemia (APL) through both a block to differentiation and …
initiates acute promyelocytic leukaemia (APL) through both a block to differentiation and …
[HTML][HTML] Acute promyelocytic leukemia (APL): a review of the literature
JJ Jimenez, RS Chale, AC Abad, AV Schally - Oncotarget, 2020 - ncbi.nlm.nih.gov
Abstract Acute Promyelocytic Leukemia (APL) is characterized by a block in differentiation
where leukemic cells are halted at the promyelocyte stage. A characteristic balanced …
where leukemic cells are halted at the promyelocyte stage. A characteristic balanced …
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
Retinoic acid and arsenic trioxide target the protein stability and transcriptional repression
activity of the fusion oncoprotein PML-RARA, resulting in regression of acute promyelocytic …
activity of the fusion oncoprotein PML-RARA, resulting in regression of acute promyelocytic …
Retinoid X receptors: common heterodimerization partners with distinct functions
Retinoid X receptors (RXRs) have been implicated in a diversity of cellular processes
ranging from cellular proliferation to lipid metabolism. These pleiotropic effects stem not only …
ranging from cellular proliferation to lipid metabolism. These pleiotropic effects stem not only …
PML-RARα/RXR alters the epigenetic landscape in acute promyelocytic leukemia
JHA Martens, AB Brinkman, F Simmer, KJ Francoijs… - Cancer cell, 2010 - cell.com
Many different molecular mechanisms have been associated with PML-RARα-dependent
transformation of hematopoietic progenitors. Here, we identified high confidence PML-RARα …
transformation of hematopoietic progenitors. Here, we identified high confidence PML-RARα …