Lung cancer is the leading cause of global cancer incidence and mortality, accounting for an
estimated 2 million diagnoses and 1.8 million deaths. Neoplasms of the lungs are the …

Smoking is a major risk factor for lung cancer, therefore lung cancer epidemiological trends
reflect the past trends of cigarette smoking to a great extent. The geographic patterns in …

Lung adenocarcinoma (LUAD) harboring EGFR mutations prevails in Asian population.
However, the inter-patient and intra-tumor heterogeneity has not been addressed at single …

Transcriptome-wide association studies (TWAS) have successfully discovered many
putative disease susceptibility genes. However, TWAS may suffer from inaccuracy of gene …

Background We characterized age at diagnosis and estimated sex differences for lung
cancer and its histological subtypes among individuals who never smoke. Methods We …

Motivation Deep neural network (DNN) algorithms were utilized in predicting various
biomedical phenotypes recently, and demonstrated very good prediction performances …

Lung cancer is the leading cause of cancer-related mortality globally, accounting for 1.8
million deaths in 2020. While the vast majority are caused by tobacco smoking, 15%− 25 …

Fourteen years after the first genome-wide association study (GWAS) of lung cancer was
published, approximately 45 genomic loci have now been significantly associated with lung …

Recently, epidermal growth factor receptor (EGFR) was a key molecule in investigation of
lung cancer, and it was a target for a new therapeutic strategy, based on molecular …

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain
only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage …