A pathological feature of Parkinson's disease (PD) is the progressive loss of dopaminergic
neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD …

Parkinson's disease (PD) is a chronic neurodegenerative condition affecting more than 1%
of people over 65 years old. It is characterized by the preferential degeneration of …

Adverse intra-and extracellular effects of toxic α-synuclein are believed to be central to the
pathogenesis in Parkinson's disease and other disorders with Lewy body pathology in the …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Protein misfolding is a general hallmark of protein deposition diseases, such as Alzheimer's
disease or Parkinson's disease, in which different types of aggregated species (oligomers …

Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …

Although a causative role of α-synuclein (α-syn) is well established in Parkinson's disease
pathogenesis, available animal models of synucleinopathy do not replicate the full range of …

Parkinson disease and dementia with Lewy bodies are featured with the formation of Lewy
bodies composed mostly of α-synuclein (α-Syn) in the brain. Although evidence indicates …

Parkinson's disease is characterized by the loss of nigrostriatal dopaminergic signaling and
the presence of alpha-synuclein aggregates (also called Lewy bodies and neurites) …

Altered degradation of α-synuclein (α-syn) has been implicated in the pathogenesis of
Parkinson disease (PD). We have shown that α-syn can be degraded via chaperone …