Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to …

JG Chase, JC Preiser, JL Dickson, A Pironet… - Biomedical engineering …, 2018 - Springer
Critical care, like many healthcare areas, is under a dual assault from significantly
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …

Consensus considerations and good practice points for use of continuous glucose monitoring systems in hospital settings

JLV Shaw, RR Bannuru, L Beach, NA ElSayed… - Diabetes …, 2024 - diabetesjournals.org
Continuous glucose monitoring (CGM) systems provide frequent glucose measurements in
interstitial fluid and have been used widely in ambulatory settings for diabetes management …

Digital twins and automation of care in the intensive care unit

J Geoffrey Chase, C Zhou, JL Knopp… - Cyber–Physical …, 2023 - Wiley Online Library
Healthcare is under increasing demand pressure as societies age and expectations rise,
multiplied by increasing incidence of chronic diseases and decreasing available funding …

Optimising mechanical ventilation through model-based methods and automation

SE Morton, JL Knopp, JG Chase, P Docherty… - Annual Reviews in …, 2019 - Elsevier
Mechanical ventilation (MV) is a core life-support therapy for patients suffering from
respiratory failure or acute respiratory distress syndrome (ARDS). Respiratory failure is a …

Digital twins in critical care: what, when, how, where, why?

JG Chase, C Zhou, JL Knopp, GM Shaw, K Näswall… - Ifac-Papersonline, 2021 - Elsevier
Healthcare and intensive care unit (ICU) medicine in particular, are facing a devastating
tsunami of rising demand multiplied by increasing chronic disease and aging demographics …

Should continuous glucose monitoring be used to manage neonates at risk of hypoglycaemia?

MS Kalogeropoulou, I Iglesias-Platas… - Frontiers in …, 2023 - frontiersin.org
The National Institute for Clinical Excellence (NICE) now recommends that continuous
glucose monitoring (CGM) be offered to adults and children with diabetes who are at risk …

Glycemic control in the intensive care unit: a control systems perspective

JG Chase, B Benyo, T Desaive - Annual Reviews in Control, 2019 - Elsevier
Computers and automation have revolutionised quality and productivity in many industries,
but not in medicine. Healthcare costs are thus growing beyond the ability of society to pay for …

Intermittent use of continuous glucose monitoring: expanding the clinical value of CGM

R Ziegler, L Heinemann, G Freckmann… - Journal of diabetes …, 2021 - journals.sagepub.com
In addition to the continuous use, the intermittent use of continuous glucose monitoring
(CGM) is an application of CGM, expanding the typical medical use cases. There are a …

Glucose management technologies for the critically ill

PD Salinas, CE Mendez - Journal of diabetes science and …, 2019 - journals.sagepub.com
Hyperglycemia is common in the intensive care unit (ICU) both in patients with and without a
previous diagnosis of diabetes. The optimal glucose range in the ICU population is still a …

[HTML][HTML] Model-based subcutaneous insulin for glycemic control of pre-term infants in the neonatal intensive care unit

T Zhou, M Boettger, JL Knopp, M Lange, A Heep… - Computers in Biology …, 2023 - Elsevier
Hyperglycaemia is a common problem in neonatal intensive care units (NICUs). Achieving
good control can result in better outcomes for patients. However, good control is difficult …