Significance: Soluble guanylyl/guanylate cyclase (sGC) is the primary receptor for nitric
oxide (NO) and is central to the physiology of blood pressure regulation, wound healing …

The diatomic molecules, O 2, NO and CO, have had a myriad of roles in biology. Due to this,
nature has developed many sensing proteins to perceive and respond to changes in the …

The chaperone heat shock protein 90 (hsp90) associates with signaling proteins in cells
including soluble guanylate cyclase (sGC). hsp90 associates with the heme-free (apo) sGC …

Some classes of bacteria within phyla possess protein sensors identified as homologous to
the heme domain of soluble guanylate cyclase, the mammalian NO-receptor. Named H-NOX …

Soluble guanylyl/guanylate cyclase (sGC) converts GTP to cGMP after binding nitric oxide,
leading to smooth muscle relaxation and vasodilation. Impaired sGC activity is common in …

Soluble guanylyl cyclase (sGC) is the receptor for nitric oxide and a highly sought-after
therapeutic target for the management of cardiovascular diseases. New compounds that …

Soluble guanylate cyclase (sGC) plays a central role in the cardiovascular system and is a
drug target for the treatment of pulmonary hypertension. While the three-dimensional …

A wide and still rapidly increasing range of heme-based sensor proteins has been
discovered over the last two decades. At the molecular level, these proteins function as …

Soluble guanylate cyclase (sGC) is a heterodimeric heme protein and the primary nitric
oxide receptor. NO binding stimulates cyclase activity, leading to regulation of …

Allosteric heme proteins can fulfill a very large number of different functions thanks to the
remarkable chemical versatility of heme through the entire living kingdom. Their efficacy …