There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC),
comprises seven phylogenetically distinct lineages associated with different geographical …

Generalist and specialist species differ in the breadth of their ecological niches. Little is
known about the niche width of obligate human pathogens. Here we analyzed a global …

Strain-specific genomic diversity in the Mycobacterium tuberculosis complex (MTBC) is an
important factor in pathogenesis that may affect virulence, transmissibility, host response …

Actinobacteria constitute one of the largest phyla among Bacteria and represent gram-
positive bacteria with a high G+ C content in their DNA. This bacterial group includes …

Molecular ty** based on 12 loci containing variable numbers of tandem repeats of
mycobacterial interspersed repetitive units (MIRU-VNTRs) has been adopted in combination …

Mycobacterium tuberculosis is an obligate human pathogen capable of persisting in
individual hosts for decades. We sequenced the genomes of 21 strains representative of the …

Among various genoty** methods to study Mycobacterium tuberculosis complex (MTC)
genotypic polymorphism, spoligoty** and mycobacterial interspersed repetitive units …

We performed the first studies of analytic sensitivity, analytic specificity, and dynamic range
for the new Xpert MTB/RIF assay, a nucleic acid amplification-based diagnostic system that …

Mycobacterium tuberculosis is a clonal pathogen proposed to have co-evolved with its
human host for millennia, yet our understanding of its genomic diversity and biogeography …