The algal past and parasite present of the apicoplast
Plasmodium and Toxoplasma are genera of apicomplexan parasites that infect millions of
people each year. The former causes malaria, and the latter causes neurotropic infections …
people each year. The former causes malaria, and the latter causes neurotropic infections …
Endocytosis in Plasmodium and Toxoplasma parasites
T Spielmann, S Gras, R Sabitzki, M Meissner - Trends in Parasitology, 2020 - cell.com
Endocytosis is critical for many functions in eukaryotic cells. Uptake of host cell cytosol, an
indispensable endocytic process in malaria blood-stage parasites, has been known for a …
indispensable endocytic process in malaria blood-stage parasites, has been known for a …
[HTML][HTML] Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook
Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …
Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting
In the apicomplexans, endocytosed cargos (eg, hemoglobin) are trafficked to a specialized
organelle for digestion. This follows a unique endocytotic process at the …
organelle for digestion. This follows a unique endocytotic process at the …
Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking
Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that
selectively target apicoplast housekee** functions, including DNA replication and protein …
selectively target apicoplast housekee** functions, including DNA replication and protein …
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13
The emergence of artemisinin (ART) resistance in Plasmodium falciparum intra-erythrocytic
parasites has led to increasing treatment failure rates with first-line ART-based combination …
parasites has led to increasing treatment failure rates with first-line ART-based combination …
The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
The emergence and spread of Plasmodium falciparum parasites resistant to front-line
antimalarial artemisinin-combination therapies (ACT) threatens to erase the considerable …
antimalarial artemisinin-combination therapies (ACT) threatens to erase the considerable …
Post-translational protein modifications in malaria parasites
Post-translational modifications play crucial parts in regulating protein function and thereby
control several fundamental aspects of eukaryotic biology, including cell signalling, protein …
control several fundamental aspects of eukaryotic biology, including cell signalling, protein …
The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp.
Highlights•Toxoplasma and Plasmodium possess two organelles of endosymbiotic origin:
the apicoplast, and the mitochondrion.•The mitochondrion hosts a complete TCA cycle and …
the apicoplast, and the mitochondrion.•The mitochondrion hosts a complete TCA cycle and …
Over 40 years of fosmidomycin drug research: a comprehensive review and future opportunities
T Knak, MA Abdullaziz, S Höfmann, LA Alves Avelar… - Pharmaceuticals, 2022 - mdpi.com
To address the continued rise of multi-drug-resistant microorganisms, the development of
novel drugs with new modes of action is urgently required. While humans biosynthesize the …
novel drugs with new modes of action is urgently required. While humans biosynthesize the …