Structure, assembly, and function of tripartite efflux and type 1 secretion systems in gram-negative bacteria

I Alav, J Kobylka, MS Kuth, KM Pos, M Picard… - Chemical …, 2021 - ACS Publications
Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence

M Alcalde-Rico, S Hernando-Amado, P Blanco… - Frontiers in …, 2016 - frontiersin.org
Multidrug efflux pumps can be involved in bacterial resistance to antibiotics at different
levels. Some efflux pumps are constitutively expressed at low levels and contribute to …

How to measure export via bacterial multidrug resistance efflux pumps

JMA Blair, LJV Piddock - MBio, 2016 - Am Soc Microbiol
Bacterial multidrug resistance (MDR) efflux pumps are an important mechanism of antibiotic
resistance and are required for many pathogens to cause infection. They are also being …

Antibacterial and efflux pump inhibitors of thymol and carvacrol against food-borne pathogens

H Miladi, T Zmantar, Y Chaabouni, K Fedhila… - Microbial …, 2016 - Elsevier
In this study thymol (THY) and carvacrol (CAR), two monoterpenic phenol produced by
various aromatic plants, was tested for their antibacterial and efflux pump inhibitors …

The Acinetobacter baumannii two-component system AdeRS regulates genes required for multidrug efflux, biofilm formation, and virulence in a strain-specific manner

GE Richmond, LP Evans, MJ Anderson, ME Wand… - MBio, 2016 - Am Soc Microbiol
The opportunistic pathogen Acinetobacter baumannii is able to persist in the environment
and is often multidrug resistant (MDR), causing difficulties in the treatment of infections …

Synergistic effect of eugenol, carvacrol, thymol, p-cymene and γ-terpinene on inhibition of drug resistance and biofilm formation of oral bacteria

H Miladi, T Zmantar, B Kouidhi, YMA Al Qurashi… - Microbial …, 2017 - Elsevier
Dental caries remains the most prevalent oral infectious disease worldwide. In this study, the
antibacterial and the antibiofilm activities of five essential oils (EO's): eugenol (EUG) …

Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis

NC Poulton, JM Rock - Frontiers in cellular and infection microbiology, 2022 - frontiersin.org
Tuberculosis (TB) is among the most difficult infections to treat, requiring several months of
multidrug therapy to produce a durable cure. The reasons necessitating long treatment times …

Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

EA Mueller, AJF Egan, E Breukink, W Vollmer… - Elife, 2019 - elifesciences.org
Although the peptidoglycan cell wall is an essential structural and morphological feature of
most bacterial cells, the extracytoplasmic enzymes involved in its synthesis are frequently …

Use of carvacrol, thymol, and eugenol for biofilm eradication and resistance modifying susceptibility of Salmonella enterica serovar Typhimurium strains to nalidixic …

H Miladi, T Zmantar, B Kouidhi, Y Chaabouni… - Microbial …, 2017 - Elsevier
The Aims of the study was to evaluate the antibacterial susceptibility and the biofilm
eradication of three natural compounds carvacrol (CAR), thymol (TH) and eugenol (EUG) …

Baicalin Inhibits Biofilm Formation and the Quorum-Sensing System by Regulating the MsrA Drug Efflux Pump in Staphylococcus saprophyticus

J Wang, H Jiao, J Meng, M Qiao, H Du, M He… - Frontiers in …, 2019 - frontiersin.org
Staphylococcus saprophyticus (S. saprophyticus) is one of the main pathogens that cause
serious infection due to its acquisition of antibiotic resistance. The efflux pump decreases …