With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …

BACKGROUND Conformational changes are essential for the correct functioning of
biological macromolecules. Time-resolved x-ray crystallography extends an extremely …

INTRODUCTION Retinal is a light-sensitive protein ligand that is used by all domains of life
to process the information and energy content of light. Retinal-binding proteins are integral …

The SwissFEL X-ray Free Electron Laser (XFEL) facility started construction at the Paul
Scherrer Institute (Villigen, Switzerland) in 2013 and will be ready to accept its first users in …

A new scientific frontier opened in 2009 with the start of operations of the world's first x-ray
free-electron laser (FEL), the Linac Coherent Light Source (LCLS), at SLAC National …

A variety of organisms have evolved mechanisms to detect and respond to light, in which the
response is mediated by protein structural changes after photon absorption. The initial step …

Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …

Utilization of renewable energies for catalytically generating value-added chemicals is
highly desirable in this era of rising energy demands and climate change impacts. Artificial …

We review the tremendous advances in ultrafast X-ray science, over the past 15 years,
making the best use of new ultrashort X-ray sources including table-top or large-scale …

The hemoprotein myoglobin is a model system for the study of protein dynamics. We used
time-resolved serial femtosecond crystallography at an x-ray free-electron laser to resolve …