Organ crosstalk and dysfunction in sepsis

A Borges, L Bento - Annals of Intensive Care, 2024 - Springer
Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Sepsis-associated organ dysfunction involves multiple inflammatory mechanisms and …

Prediction of subclinical and clinical multiple organ failure dysfunction in breast cancer patients—a review using AI tools

AI Ionescu, DI Atasiei, RT Ionescu, F Ultimescu… - Cancers, 2024 - mdpi.com
Simple Summary The paper discusses precursor lesions of breast cancer and the
subclinical syndrome of multiple organ failure, representing early disease stages with …

Neutrophils and the systemic inflammatory response syndrome (SIRS)

JP Sikora, J Karawani, J Sobczak - International Journal of Molecular …, 2023 - mdpi.com
We are not entirely able to understand, assess, and modulate the functioning of the immune
system in clinical situations that lead to a systemic inflammatory response. In the search for …

L-AP Alleviates Liver Injury in Septic Mice by Inhibiting Macrophage Activation via Suppressing NF-κB and NLRP3 Inflammasome/Caspase-1 Signal Pathways

L Liu, L Lin, Y Wang, X Yan, R Li, M He… - Journal of Agricultural …, 2024 - ACS Publications
Liver injury and progressive liver failure are severe life-threatening complications in sepsis,
further worsening the disease and leading to death. Macrophages and their mediated …

Bacterial infections among patients with chronic diseases at a tertiary care hospital in Saudi Arabia

AS Bazaid, AA Punjabi, A Aldarhami, H Qanash… - Microorganisms, 2022 - mdpi.com
Infections caused by multi-drug-resistant bacteria in patients with chronic diseases have
been associated with high mortality and morbidity. While few reports have evaluated …

Organotypic heterogeneity in microvascular endothelial cell responses in sepsis—a molecular treasure trove and pharmacological Gordian knot

A Cleuren, G Molema - Frontiers in Medicine, 2023 - frontiersin.org
In the last decades, it has become evident that endothelial cells (ECs) in the
microvasculature play an important role in the pathophysiology of sepsis-associated multiple …

[HTML][HTML] Antioxidant and anti-aging role of silk sericin in D-galactose induced mice model

S Mumtaz, S Ali, MZ Qureshi, A Muhammad… - Saudi Journal of …, 2023 - Elsevier
The main purpose was to elucidate the potential anti-aging impact of sericin, due to its anti-
oxidant potential in D-galactose induced mice model. To induce natural aging in mice, a …

Nitric oxide: Potential therapeutic target in Heat Stress–induced Multiple Organ Dysfunction

P Jaswal, S Bansal, R Chaudhary, J Basu… - Naunyn-Schmiedeberg's …, 2024 - Springer
As climate change intensifies, urgent action is needed to address global warming and its
associated health risks, particularly in vulnerable regions. Rising global temperature and …

Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body …

FP Costa, B Wiedenmann, E Schöll… - Frontiers in Network …, 2024 - frontiersin.org
A steadily increasing number of publications support the concept of physiological networks,
and how cellular bioelectrical properties drive cell proliferation and cell synchronization. All …

Exogenous IL‐10 posttreatment along with TLR4 and TNFR1 blockade improves tissue antioxidant status by modulating sepsis‐induced macrophage polarization

R Sawoo, R Dey, R Ghosh… - Journal of Applied …, 2023 - Wiley Online Library
Multi‐organ dysfunction is one of the major reasons behind the high mortality of sepsis
throughout the world. With the pathophysiology of sepsis remaining largely unknown, the …