Neurodegenerative diseases exert an overwhelming socioeconomic burden all around the
globe. They are mainly characterized by modified protein accumulation that might trigger …

Neurodegenerative disease is a collective term given for the clinical condition, which results
in progressive degeneration of neurons and the loss of functions associated with the …

Background Brain iron is an essential as well as a toxic redox active element. Physiological
levels are not uniform among the different cell types. Besides the availability of quantitative …

Iron is indispensable in numerous biologic processes, but abnormal iron regulation and
accumulation is related to pathological processes in cardiovascular diseases. However, the …

Significance: Traumatic spinal cord injury (SCI) causes significant disruption to neuronal,
glial, vascular, and extracellular elements. The spinal cord extracellular matrix (ECM) …

Autophagy generally refers to cell catabolic and recycling process in which cytoplasmic
components are delivered to lysosomes for degradation. During the last two decades …

Neuroinflammation plays a crucial role in the occurrence and development of cognitive
impairment in type 2 diabetes mellitus (T2DM), but the specific injury mechanism is not fully …

The xanthophyll carotenoid lutein has been widely used as supplementation due to its
protective effects in light-induced oxidative stress. Its antioxidant and anti-inflammatory …

Neurodegeneration with brain iron accumulation (NBIA) comprises a heterogeneous group
of progressive disorders with the common feature of excessive iron deposition in the brain …

Neurodegenerative disorders are featured by a variety of pathological conditions that share
similar critical processes, such as oxidative stress, free radical activity, proteinaceous …