Mechanisms and concepts in RNA virus population dynamics and evolution

PT Dolan, ZJ Whitfield, R Andino - Annual Review of Virology, 2018 - annualreviews.org
RNA viruses are unique in their evolutionary capacity, exhibiting high mutation rates and
frequent recombination. They rapidly adapt to environmental changes, such as shifts in …

Variation in recombination rate: adaptive or not?

KR Ritz, MAF Noor, ND Singh - Trends in Genetics, 2017 - cell.com
Rates of meiotic recombination are widely variable both within and among species.
However, the functional significance of this variation remains largely unknown. Is the …

HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations

N Drayman, P Patel, L Vistain, S Tay - Elife, 2019 - elifesciences.org
Viral infection is usually studied at the population level by averaging over millions of cells.
However, infection at the single-cell level is highly heterogeneous, with most infected cells …

RNA recombination enhances adaptability and is required for virus spread and virulence

Y ** the evolutionary potential of RNA viruses
PT Dolan, ZJ Whitfield, R Andino - Cell host & microbe, 2018 - cell.com
The deterministic force of natural selection and stochastic influence of drift shape RNA virus
evolution. New deep-sequencing and microfluidics technologies allow us to quantify the …

Comprehensive analysis of genomic diversity of SARS-CoV-2 in different geographic regions of India: an endeavour to classify Indian SARS-CoV-2 strains on the …

R Sarkar, S Mitra, P Chandra, P Saha, A Banerjee… - Archives of …, 2021 - Springer
Accumulation of mutations within the genome is the primary driving force in viral evolution
within an endemic setting. This inherent feature often leads to altered virulence, infectivity …