Role of ion channels and transporters in cell migration

A Schwab, A Fabian, PJ Hanley… - Physiological …, 2012 - journals.physiology.org
Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Cancer as a channelopathy: ion channels and pumps in tumor development and progression

A Litan, SA Langhans - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Increasing evidence suggests that ion channels and pumps not only regulate membrane
potential, ion homeostasis, and electric signaling in excitable cells but also play important …

Distribution and function of voltage-gated sodium channels in the nervous system

J Wang, SW Ou, YJ Wang - Channels, 2017 - Taylor & Francis
Voltage-gated sodium channels (VGSCs) are the basic ion channels for neuronal
excitability, which are crucial for the resting potential and the generation and propagation of …

Anticancer steroids: linking natural and semi-synthetic compounds

JAR Salvador, JFS Carvalho, MAC Neves… - Natural product …, 2013 - pubs.rsc.org
Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …

Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an …

D Lamoral-Theys, A Andolfi… - Journal of medicinal …, 2009 - ACS Publications
Twenty-two lycorine-related compounds were investigated for in vitro antitumor activity using
four cancer cell lines displaying different levels of resistance to proapoptotic stimuli and two …

[HTML][HTML] Anticancer and antiviral properties of cardiac glycosides: a review to explore the mechanism of actions

D Reddy, R Kumavath, D Barh, V Azevedo, P Ghosh - Molecules, 2020 - mdpi.com
Cardiac glycosides (CGs) have a long history of treating cardiac diseases. However, recent
reports have suggested that CGs also possess anticancer and antiviral activities. The …

Anticancer and immunogenic properties of cardiac glycosides

NFZ Schneider, C Cerella, CMO Simões, M Diederich - Molecules, 2017 - mdpi.com
Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several
cardiac conditions and more recently have been recognized as potential antitumor …

Evaluating the cancer therapeutic potential of cardiac glycosides

JM Calderón-Montaño, E Burgos-Morón… - BioMed research …, 2014 - Wiley Online Library
Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that
share a steroid‐like structure with an unsaturated lactone ring and the ability to induce …

Recent advances on marine mollusk-derived natural products: chemistry, chemical ecology and therapeutical potential

ZH Chen, YW Guo, XW Li - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2011–2021 Marine mollusks, which are well known as rich sources of diverse and
biologically active natural products, have attracted significant attention from researchers due …

Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials

M Slingerland, C Cerella, HJ Guchelaar… - Investigational new …, 2013 - Springer
Cardiac glycosides have a long history in the treatment of cardiac disease. However, several
preclinical studies as well as two phase I studies have shown that cardenolides may also …