RNA modifications in cancer
Q Tang, L Li, Y Wang, P Wu, X Hou, J Ouyang… - British journal of …, 2023 - nature.com
Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …
modifications, various methylations account for two-thirds of total cases and exist on almost …
Emerging roles of tRNA-derived fragments in cancer
M Fu, J Gu, M Wang, J Zhang, Y Chen, P Jiang, T Zhu… - Molecular cancer, 2023 - Springer
Abstract tRNA-derived fragments (tRFs) are an emerging category of small non-coding
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …
The life and times of a tRNA
The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …
and insights in the last several years. We now have unprecedented knowledge of each step …
Roles and regulation of tRNA-derived small RNAs in animals
S Muthukumar, CT Li, RJ Liu, C Bellodi - Nature Reviews Molecular Cell …, 2024 - nature.com
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
Small RNA modifications: regulatory molecules and potential applications
Q **ong, Y Zhang - Journal of Hematology & Oncology, 2023 - Springer
Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric
ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of …
ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of …
tRNA renovatio: rebirth through fragmentation
Summary tRNA function is based on unique structures that enable mRNA decoding using
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …
Alkaline phosphatase-controllable and red light-activated RNA modification approach for precise tumor suppression
J Fang, Y Feng, Y Zhang, A Wang, J Li… - Journal of the …, 2022 - ACS Publications
RNA interference (RNAi) has proved to be a promising modality for disease treatment.
However, the promise of conventional RNA therapeutics for clinical application is severely …
However, the promise of conventional RNA therapeutics for clinical application is severely …
[HTML][HTML] N1-methyladenosine modification in cancer biology: Current status and future perspectives
J Li, H Zhang, H Wang - Computational and Structural Biotechnology …, 2022 - Elsevier
Post-transcriptional modifications in RNAs regulate their biological behaviors and functions.
N 1-methyladenosine (m 1 A), which is dynamically regulated by writers, erasers and …
N 1-methyladenosine (m 1 A), which is dynamically regulated by writers, erasers and …
Transfer RNA-derived small RNAs in tumor microenvironment
M Yang, Y Mo, D Ren, S Liu, Z Zeng, W **ong - Molecular cancer, 2023 - Springer
Transfer RNAs (tRNAs) are a class of non-coding RNAs responsible for amino acid
translocation during protein synthesis and are ubiquitously found in organisms. With certain …
translocation during protein synthesis and are ubiquitously found in organisms. With certain …
Writers, readers, and erasers RNA modifications and drug resistance in cancer
D Chen, X Gu, Y Nurzat, L Xu, X Li, L Wu, H Jiao… - Molecular Cancer, 2024 - Springer
Drug resistance in cancer cells significantly diminishes treatment efficacy, leading to
recurrence and metastasis. A critical factor contributing to this resistance is the epigenetic …
recurrence and metastasis. A critical factor contributing to this resistance is the epigenetic …