Rethinking schizophrenia

TR Insel - Nature, 2010 - nature.com
How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently
disabling mental disorder that affects about one per cent of the world's population. After a …

The NMDA receptor and schizophrenia: from pathophysiology to treatment

DT Balu - Advances in pharmacology, 2016 - Elsevier
Schizophrenia is a severe mental illness that affects almost 1% of the population worldwide.
Even though the etiology of schizophrenia is uncertain, it is believed to be a …

Heritability of schizophrenia and schizophrenia spectrum based on the nationwide Danish twin register

R Hilker, D Helenius, B Fagerlund, A Skytthe… - Biological …, 2018 - Elsevier
Background Twin studies have provided evidence that both genetic and environmental
factors contribute to schizophrenia (SZ) risk. Heritability estimates of SZ in twin samples …

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

Nature genetics, 2011 - nature.com
We conducted a combined genome-wide association study (GWAS) of 7,481 individuals
with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS …

Dendritic spine pathology in schizophrenia

JR Glausier, DA Lewis - Neuroscience, 2013 - Elsevier
Schizophrenia is a neurodevelopmental disorder whose clinical features include
impairments in perception, cognition and motivation. These impairments reflect alterations in …

Incidence of schizophrenia and other psychoses in England, 1950–2009: a systematic review and meta-analyses

JB Kirkbride, A Errazuriz, TJ Croudace, C Morgan… - PloS one, 2012 - journals.plos.org
Background We conducted a systematic review of incidence rates in England over a sixty-
year period to determine the extent to which rates varied along accepted (age, sex) and less …

Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies

PF Sullivan, KS Kendler, MC Neale - Archives of general …, 2003 - jamanetwork.com
Context There are many published twin studies of schizophrenia. Although these studies
have been reviewed previously, to our knowledge, no review has provided quantitative …

Current findings and perspectives on aberrant neural oscillations in schizophrenia

Y Hirano, PJ Uhlhaas - Psychiatry and clinical neurosciences, 2021 - Wiley Online Library
There is now consistent evidence that neural oscillation at low‐and high‐frequencies
constitute an important aspect of the pathophysiology of schizophrenia. Specifically …

The heritability of bipolar affective disorder and the genetic relationship to unipolar depression

P McGuffin, F Rijsdijk, M Andrew, P Sham… - Archives of general …, 2003 - jamanetwork.com
Background Twin studies of bipolar affective disorder (BPD) have either been small or have
not used explicit diagnostic criteria. There has been little use of genetic model fitting and no …