Major goal of structural biology involve formation of protein-ligand complexes; in which the
protein molecules act energetically in the course of binding. Therefore, perceptive of protein …

Highly selective angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) are now
available. The AT1 receptor is a member of the G protein-coupled receptor (GPCR) …

Hypertension is the most common cause of left ventricular hypertrophy, contributing to heart
failure progression. Candesartan (Cand) is an angiotensin receptor antagonist widely used …

Hypertension is a major risk factor for human morbidity and mortality through its effects on
target organs like heart, brain and kidneys. More intensive treatment for the effective control …

The aim of this work was to answer the question of whether the general amber force field
(GAFF) is good enough to simulate fully hydrated POPC membrane bilayers. The test system …

The renin–angiotensin system (RAS) plays an important role in the pathophysiology of
cardiovascular disorders. Pharmacologic interventions targeting the RAS cascade have led …

In the last decades, homology modeling has become a popular tool to access theoretical
three-dimensional (3D) structures of molecular targets. So far several 3D models of proteins …

Introduction: Benzimidazole is a heterocyclic aromatic system, which is part of some natural
and many synthetic compounds. A large number of benzimidazoles and its derivatives are …

Abstract The Monte Carlo method was used for QSAR modelling 2, 4-dihydro-3 H-1, 2, 4-
triazol-3-ones derivatives as angiotensin II AT 1 receptor antagonists. QSAR models were …

A series of 5-(alkyl and aryl) carboxamido benzimidazole derivatives had been designed,
synthesized and evaluated for in vitro angiotensin II–AT1 receptor antagonism and in vivo …