[HTML][HTML] Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke

Z Shen, M **ang, C Chen, F Ding, Y Wang… - Biomedicine & …, 2022‏ - Elsevier
Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

[HTML][HTML] The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury

J Huang, L Chen, Z Yao, X Sun, X Tong… - Biomedicine & …, 2023‏ - Elsevier
Stroke is one of the leading causes of death and long-term disability worldwide. More than
80% of strokes are ischemic, caused by an occlusion of cerebral arteries. Without question …

[HTML][HTML] Applications of metabolomics in forensic toxicology and forensic medicine

M Szeremeta, K Pietrowska… - International Journal of …, 2021‏ - mdpi.com
Forensic toxicology and forensic medicine are unique among all other medical fields
because of their essential legal impact, especially in civil and criminal cases. New high …

Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation

A Miller, EM York, SA Stopka, JR Martínez-François… - Nature …, 2023‏ - nature.com
Neuronal activity creates an intense energy demand that must be met by rapid metabolic
responses. To investigate metabolic adaptations in the neuron-enriched dentate granule cell …

[HTML][HTML] Pharmacological effects of salidroside on central nervous system diseases

M **, C Wang, Y Xu, Z Zhang, X Wu, R Ye… - Biomedicine & …, 2022‏ - Elsevier
Salidroside (SAL) is a phenylpropanoid glycoside monomer extracted from Rhodiola at high
altitudes. It has been proven to have protective effects on myocardial injury, liver cancer …

[HTML][HTML] Unsupervised anomaly detection in brain MRI: Learning abstract distribution from massive healthy brains

G Luo, W **e, R Gao, T Zheng, L Chen… - Computers in biology and …, 2023‏ - Elsevier
Purpose To develop a general unsupervised anomaly detection method based only on MR
images of normal brains to automatically detect various brain abnormalities. Materials and …

Neuroprotective mechanisms of puerarin in central nervous system diseases: Update

CC Yu, YJ Du, J Li, Y Li, L Wang, LH Kong… - Aging and …, 2022‏ - pmc.ncbi.nlm.nih.gov
Due to global population aging and modern lifestyle changes, the incidence of central
nervous system (CNS) disorders, such as neurodegenerative diseases, neuropsychiatric …

[HTML][HTML] Novel insight into the role of A-kinase anchoring proteins (AKAPs) in ischemic stroke and therapeutic potentials

Z He, L **e, J Liu, X Wei, W Zhang, Z Mei - Biomedicine & Pharmacotherapy, 2024‏ - Elsevier
Ischemic stroke, a devastating disease associated with high mortality and disability
worldwide, has emerged as an urgent public health issue. A-kinase anchoring proteins …

The SIRT1-HMGB1 axis: Therapeutic potential to ameliorate inflammatory responses and tumor occurrence

L Wei, W Zhang, Y Li, J Zhai - Frontiers in Cell and Developmental …, 2022‏ - frontiersin.org
Inflammation is a common complication of many chronic diseases. It includes inflammation
of the parenchyma and vascular systems. Sirtuin 1 (SIRT1) is a nicotinamide adenine …

Phenylacetylglutamine, a novel biomarker in acute ischemic stroke

F Yu, X Li, X Feng, M Wei, Y Luo, T Zhao… - Frontiers in …, 2021‏ - frontiersin.org
Background: To discover novel metabolic biomarkers of ischemic stroke (IS), we carried out
a two-stage metabolomic profiling of IS patients and healthy controls using untargeted and …