The use of electronic (e)-cigarettes was initially considered a beneficial solution to
conventional cigarette smoking cessation. However, paradoxically, e-cigarette use is rapidly …

There are a variety of medical conditions associated with chronic sinonasal inflammation,
including chronic rhinosinusitis (CRS) and cystic fibrosis. In particular, CRS can be divided …

Various lung insults can result in replacement of resident alveolar macrophages (AM) by
bone marrow monocyte–derived (BMo)–AM. However, the dynamics of this process and its …

Tissue-resident memory T cells (TRM cells) in the airways mediate protection against
respiratory infection. We characterized TRM cells expressing integrin αE (CD103) that reside …

Innate and adaptive defense mechanisms protect the respiratory system from attack by
microbes. Here, we present evidence that the bitter taste receptor T2R38 regulates the …

Bitter taste receptors (T2Rs) in the human airway detect harmful compounds, including
secreted bacterial products. Here, using human primary sinonasal air-liquid interface …

Novel affinity-purified antibodies against human SGLT1 (hSGLT1) and SGLT2 (hSGLT2)
were used to localize hSGLT2 in human kidney and hSGLT1 in human kidney, small …

Respiratory tract infections are an important cause of morbidity and mortality worldwide.
Chief among these are infections involving the lower airways. The opportunistic bacterial …

Taste receptors were first identified on the tongue, where they initiate a signaling pathway
that communicates information to the brain about the nutrient content or potential toxicity of …

SARS-CoV-2 started spreading toward the end of 2019 causing COVID-19, a disease that
reached pandemic proportions among the human population within months. The reasons for …