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Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis
Crosstalk between gut and brain has long been appreciated in health and disease, and the
gut microbiota is a key player in communication between these two distant organs. Yet, the …
gut microbiota is a key player in communication between these two distant organs. Yet, the …
Neurobiology and systems biology of stress resilience
R Kalisch, SJ Russo, MB Müller - Physiological reviews, 2024 - journals.physiology.org
Stress resilience is the phenomenon that some people maintain their mental health despite
exposure to adversity or show only temporary impairments followed by quick recovery …
exposure to adversity or show only temporary impairments followed by quick recovery …
Central regulation of stress-evoked peripheral immune responses
Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are
associated with systemic inflammation. Recent studies have reported stress-induced …
associated with systemic inflammation. Recent studies have reported stress-induced …
Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential
M Yuan, B Yang, G Rothschild, JJ Mann… - Signal transduction and …, 2023 - nature.com
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …
SGLT2 inhibition via empagliflozin improves endothelial function and reduces mitochondrial oxidative stress: insights from frail hypertensive and diabetic patients
Background: Frailty is a multidimensional condition often diagnosed in older adults with
hypertension and diabetes, and both these conditions are associated with endothelial …
hypertension and diabetes, and both these conditions are associated with endothelial …
Psychological resilience: An update on definitions, a critical appraisal, and research recommendations
Background: The ability to resist adverse outcomes, or demonstrate resilience after
exposure to trauma is a thriving field of study. Yet ongoing debate persists regarding …
exposure to trauma is a thriving field of study. Yet ongoing debate persists regarding …
Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue
Prevalence, symptoms, and treatment of depression suggest that major depressive
disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is …
disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is …
The CLDN5 gene at the blood-brain barrier in health and disease
The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and
forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain …
forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain …
Association between vascular endothelial growth factor-mediated blood–brain barrier dysfunction and stress-induced depression
H Matsuno, S Tsuchimine, K O'Hashi, K Sakai… - Molecular …, 2022 - nature.com
Several lines of evidence suggest that stress induces the neurovascular dysfunction
associated with increased blood–brain barrier (BBB) permeability, which could be an …
associated with increased blood–brain barrier (BBB) permeability, which could be an …
Neurobiological basis of stress resilience
A majority of humans faced with severe stress maintain normal physiological and behavioral
function, a process referred to as resilience. Such stress resilience has been modeled in …
function, a process referred to as resilience. Such stress resilience has been modeled in …