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[HTML][HTML] Integrative multi-omics approaches in cancer research: from biological networks to clinical subtypes
Multi-omics approaches are novel frameworks that integrate multiple omics datasets
generated from the same patients to better understand the molecular and clinical features of …
generated from the same patients to better understand the molecular and clinical features of …
Circulating biomarkers for gliomas
M Westphal, K Lamszus - Nature Reviews Neurology, 2015 - nature.com
Currently, gliomas are diagnosed by neuroimaging, and refined diagnosis requires
resection or biopsy to obtain tumour tissue for histopathological classification and grading …
resection or biopsy to obtain tumour tissue for histopathological classification and grading …
[HTML][HTML] Phosphoproteome integration reveals patient-specific networks in prostate cancer
We used clinical tissue from lethal metastatic castration-resistant prostate cancer (CRPC)
patients obtained at rapid autopsy to evaluate diverse genomic, transcriptomic, and …
patients obtained at rapid autopsy to evaluate diverse genomic, transcriptomic, and …
Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance
AB Nagaraj, P Joseph, O Kovalenko, S Singh… - …, 2015 - pmc.ncbi.nlm.nih.gov
Resistance to platinum-based chemotherapy is the major barrier to treating epithelial
ovarian cancer. To improve patient outcomes, it is critical to identify the underlying …
ovarian cancer. To improve patient outcomes, it is critical to identify the underlying …
Network-based interpretation of diverse high-throughput datasets through the omics integrator software package
High-throughput,'omic'methods provide sensitive measures of biological responses to
perturbations. However, inherent biases in high-throughput assays make it difficult to …
perturbations. However, inherent biases in high-throughput assays make it difficult to …
Revealing disease-associated pathways by network integration of untargeted metabolomics
Uncovering the molecular context of dysregulated metabolites is crucial to understand
pathogenic pathways. However, their system-level analysis has been limited owing to …
pathogenic pathways. However, their system-level analysis has been limited owing to …
Cancer systems biology: a peek into the future of patient care?
Traditionally, scientific research has focused on studying individual events, such as single
mutations, gene function, or the effect that mutating one protein has on a biological …
mutations, gene function, or the effect that mutating one protein has on a biological …
Molecular network analysis of endometriosis reveals a role for c-Jun–regulated macrophage activation
Clinical management of endometriosis is limited by the complex relationship between
symptom severity, heterogeneous surgical presentation, and variability in clinical outcomes …
symptom severity, heterogeneous surgical presentation, and variability in clinical outcomes …
Large-scale models of signal propagation in human cells derived from discovery phosphoproteomic data
Mass spectrometry is widely used to probe the proteome and its modifications in an
untargeted manner, with unrivalled coverage. Applied to phosphoproteomics, it has …
untargeted manner, with unrivalled coverage. Applied to phosphoproteomics, it has …
Elucidating MicroRNA regulatory networks using transcriptional, post-transcriptional, and histone modification measurements
MicroRNAs (miRNAs) regulate diverse biological processes by repressing mRNAs, but their
modest effects on direct targets, together with their participation in larger regulatory …
modest effects on direct targets, together with their participation in larger regulatory …