MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease
Fatty liver associated with metabolic dysfunction is common, affects a quarter of the
population, and has no approved drug therapy. Although pharmacotherapies are in …
population, and has no approved drug therapy. Although pharmacotherapies are in …
Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
A single-cell atlas of human and mouse white adipose tissue
White adipose tissue, once regarded as morphologically and functionally bland, is now
recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of …
recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of …
Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)
Key questions in COVID-19 are the duration and determinants of infectious virus shedding.
Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 …
Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 …
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
Mendelian randomisation uses genetic variation as a natural experiment to investigate the
causal relations between potentially modifiable risk factors and health outcomes in …
causal relations between potentially modifiable risk factors and health outcomes in …
Reassessing human adipose tissue
AM Cypess - New England Journal of Medicine, 2022 - Mass Medical Soc
Reassessing Human Adipose Tissue Adipose tissue can more than double in mass and
then return to baseline. This review discusses the functional roles of human white and brown …
then return to baseline. This review discusses the functional roles of human white and brown …
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
Fine-map** type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels …
European-descent individuals (9% cases), after imputation to high-density reference panels …
The integrative biology of type 2 diabetes
M Roden, GI Shulman - Nature, 2019 - nature.com
Obesity and type 2 diabetes are the most frequent metabolic disorders, but their causes
remain largely unclear. Insulin resistance, the common underlying abnormality, results from …
remain largely unclear. Insulin resistance, the common underlying abnormality, results from …
Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases
Microbiome-wide association studies on large population cohorts have highlighted
associations between the gut microbiome and complex traits, including type 2 diabetes …
associations between the gut microbiome and complex traits, including type 2 diabetes …