Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach

A Cuadrado, G Manda, A Hassan, MJ Alcaraz… - Pharmacological …, 2018 - Elsevier
Abstract Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

Metallothioneins in aquatic invertebrates: their role in metal detoxification and their use as biomarkers

JC Amiard, C Amiard-Triquet, S Barka, J Pellerin… - Aquatic toxicology, 2006 - Elsevier
The literature on metallothioneins (MT) and metallothionein-like proteins (MTLP) in aquatic
invertebrates is large and increasing, and yet inconsistencies and confusion remain, not …

Uptake and Effects of Microplastics on Cells and Tissue of the Blue Mussel Mytilus edulis L. after an Experimental Exposure

N Von Moos, P Burkhardt-Holm… - Environmental science & …, 2012 - ACS Publications
In this study, we investigated if industrial high-density polyethylene (HDPE) particles, a
model microplastic free of additives, ranging> 0–80 μm are ingested and taken up into the …

Pharmaceuticals in the aquatic environments: evidence of emerged threat and future challenges for marine organisms

M Mezzelani, S Gorbi, F Regoli - Marine environmental research, 2018 - Elsevier
Pharmaceuticals are nowadays recognized as a threat for aquatic ecosystems. The growing
consumption of these compounds and the enhancement of human health in the past two …

Get rid of marine pollution: bioremediation an innovative, attractive, and successful cleaning strategy

V Aliko, CR Multisanti, B Turani, C Faggio - Sustainability, 2022 - mdpi.com
Aquatic environmental pollution is a rather worrying and increasingly topical problem that
requires the development and promotion of innovative and ecofriendly technologies …

The use of biomarkers in biomonitoring: a 2-tier approach assessing the level of pollutant-induced stress syndrome in sentinel organisms

A Viarengo, D Lowe, C Bolognesi, E Fabbri… - … and Physiology Part C …, 2007 - Elsevier
The paper outlines a 2-tier approach for wide-scale biomonitoring programmes. To obtain a
high level of standardization, we suggest the use of caged organisms (mussels or fish). An …

[HTML][HTML] Health risk assessment and levels of toxic metals in fishes (Oreochromis noliticus and Clarias anguillaris) from Ankobrah and Pra basins: Impact of illegal …

NK Kortei, ME Heymann, EK Essuman, FM Kpodo… - Toxicology Reports, 2020 - Elsevier
Abstract Arsenic (As), mercury (Hg), Cadmium (Cd) and lead (Pb) are toxic heavy metals that
naturally occur in the ecosystem. Their levels are on the rise due to anthropogenic activities …

The application of histo-cytopathological biomarkers in marine pollution monitoring: a review

DWT Au - Marine pollution bulletin, 2004 - Elsevier
During the past two decades, a variety of histopathological alterations in fish and bivalves
have been developed and used as biomarkers in pollution monitoring. Some of these have …

MicroRNAs and their role on fish oxidative stress during xenobiotic environmental exposures

MA Burgos-Aceves, A Cohen, Y Smith… - … and Environmental safety, 2018 - Elsevier
There is a growing global concern about the health implications of xenobiotics, which have
harmful effects to both humans and wildlife. Among them, teleost fish are known as very …

Environmentally relevant concentration of cypermethrin or/and sulfamethoxazole induce neurotoxicity of grass carp: involvement of blood-brain barrier, oxidative …

H Zhao, Y Wang, M Guo, Y Liu, H Yu, M **ng - Science of the Total …, 2021 - Elsevier
In water environment, the interaction between environmental pollutants is very complex,
among which pesticides and antibiotics are dominant. However, most studies only focus on …