Cardiac fibrosis is a critical pathophysiological process that occurs with diverse types of
cardiac injury. Lipids are the most important bioenergy substrates for maintaining optimal …

Chronic kidney disease is associated with an increased risk for the development and
progression of cardiovascular disorders including hypertension, dyslipidemia, and coronary …

Background Observational reports suggest that supplementation that increases citric acid
cycle intermediates via anaplerosis may have therapeutic advantages over traditional …

Background The treatment of long-chain mitochondrial β-oxidation disorders (LC-FOD) with
a low fat-high carbohydrate diet, a diet rich in medium-even-chain triglycerides (MCT), or a …

Heart failure (HF) is a complex syndrome and a leading cause of mortality worldwide. While
current medical treatment is based on known pathophysiology and is effective for many …

Despite considerable progress in treating cardiac disorders, the prevalence of heart failure
(HF) keeps growing, making it a global medical and economic burden. HF is characterized …

A healthy heart relies on an intact cardiac lipid metabolism. Fatty acids represent the major
source for ATP production in the heart. Not less importantly, lipids are directly involved in …

Heart failure occurs because of various cardiovascular pathologies, such as coronary artery
disease or cardiorenal syndrome, eventually reaching end‐stage disease. Various factors …

Background Left ventricular hypertrophy (LVH) is characterized by a decrease in oxidation of
long-chain fatty acids, possibly mediated by reduced expression of the cell-surface protein …

A rather new approach in the treatment of long-chain fatty acid oxidation disorders is
represented by triheptanoin, a triglyceride with three medium-odd-chain heptanoic acids …