Synthesis and in silico studies of certain benzo[f]quinoline-based heterocycles as antitumor agents

EAE El-Helw, M Asran, ME Azab, MH Helal… - Scientific Reports, 2024 - nature.com
A series of benzoquinoline-employing heterocycles was synthesized by treating 3-
chlorobenzo [f] quinoline-2-carbaldehyde with N-phenyl-3-methylpyrazolone, 4 …

Synthesis, spectroscopic, DFT calculations, biological activity, SAR, and molecular docking studies of novel bioactive pyridine derivatives

KE Anwer, ZK Hamza, RM Ramadan - Scientific Reports, 2023 - nature.com
Enaminonitrile pyridine derivative was used as a precursor for preparation of fourteen
heterocyclic compounds using both conventional thermal and microwave techniques …

[HTML][HTML] Discovery of new Schiff bases tethered pyrazole moiety: Design, synthesis, biological evaluation, and molecular docking study as dual targeting DHFR/DNA …

AS Hassan, AA Askar, AM Naglah, AA Almehizia… - Molecules, 2020 - mdpi.com
A series of Bis-pyrazole Schiff bases (6a–d and 7a–d) and mono-pyrazole Schiff bases (8a–
d and 9a–d) were designed and synthesized through the reaction of 5-aminopyrazoles 1a–d …

Novel pyridine bearing pentose moiety-based anticancer agents: design, synthesis, radioiodination and bioassessments

MM Mehany, OA Hammam, AA Selim, GH Sayed… - Scientific Reports, 2024 - nature.com
Pyridine compounds are one of the most important heterocyclic derivatives showing wide
ranges in biological and pharmacological activities. Green chemistry eliminates or reduces …

Design, synthesis, and molecular docking study of novel heterocycles incorporating 1, 3, 4-thiadiazole moiety as potential antimicrobial and anticancer agents

M El-Naggar, HA Sallam, SS Shaban… - Molecules, 2019 - mdpi.com
A new series of 5-(3, 5-dinitrophenyl)-1, 3, 4-thiadiazole derivatives were prepared and
evaluated for their in vitro antimicrobial, antitumor, and DHFR inhibition activity. Compounds …

Conventional and microwave-assisted synthesis, anticancer evaluation, 99mTc-coupling and In-vivo study of some novel pyrazolone derivatives

BM Essa, AA Selim, GH Sayed, KE Anwer - Bioorganic Chemistry, 2022 - Elsevier
New pyrazolone derivatives were successfully synthesized by both microwave-assisted and
conventional techniques. Compound 3 (3-(3-Methyl-5-oxo-4, 5-dihydro-1H-pyrazol-1-yl)-3 …

Conventional and microwave reactions of 1, 3‐diaryl‐5, 4‐enaminonitrile‐pyrazole derivative with expected antimicrobial and anticancer activities

KE Anwer, GH Sayed - Journal of heterocyclic chemistry, 2020 - Wiley Online Library
The present study illustrates conventional and microwave reactions of 5‐amino‐1, 3‐diaryl‐
pyrazole‐4‐carbonitrile derivative with phenacyl bromide under different conditions …

Synthesis and biological activity of a new class of enaminonitrile pyrazole

S Mohamed, N Dawoud, SN Shabaan… - Egyptian Journal of …, 2021 - ejchem.journals.ekb.eg
The present work illustrates the treatment of 5-amino-1, 3-diphenyl-1H-pyrazole-4-
carbonitrile (1) with maleic, phthalic anhydrides, acetyl chloride, and benzene sulfonyl …

Synthesis and Antiproliferative Screening of Some Heterocycles Derived from 4-((5-Chloro-3-Methyl-1-Phenyl-1H-Pyrazol-4-yl)Methylene)-2-Phenyloxazol-5(4H) …

YM Youssef, ME Azab, GA Elsayed… - Polycyclic Aromatic …, 2023 - Taylor & Francis
A new series of pyrazole derivatives was synthesized starting from the pyrazole-based
oxazolone derivative 3. The activity of compound 3 toward some mono-and bidentate …

Synthesis and anticancer assessment of some new 2-amino-3-cyanopyridine derivatives

SY Mansour, GH Sayed, MI Marzouk… - Synthetic …, 2021 - Taylor & Francis
The 2-Aminonicotinonitrile derivative was reacted with different bi-functional reagents such
as formamide, thiourea, acetic anhydride, and phthalic anhydride under optimized …