Lung cell atlases in health and disease

TS Adams, A Marlier, N Kaminski - Annual review of physiology, 2023 - annualreviews.org
The human lung cellular portfolio, traditionally characterized by cellular morphology and
individual markers, is highly diverse, with over 40 cell types and a complex branching …

Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis

AA Raslan, TX Pham, J Lee, K Kontodimas… - Nature …, 2024 - nature.com
Progressive lung fibrosis is associated with poorly understood aging-related endothelial cell
dysfunction. To gain insight into endothelial cell alterations in lung fibrosis we performed …

Development trends of human organoid‐based COVID‐19 research based on bibliometric analysis

M Li, Y Yuan, T Zou, Z Hou, L **, B Wang - Cell Proliferation, 2023 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), a global pandemic caused by the severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has posed a catastrophic threat …

Transcriptomics analysis identifies the decline in the alveolar type II stem cell niche in aged human lungs

X Liu, X Zhang, C Yao, J Liang, PW Noble… - American Journal of …, 2024 - atsjournals.org
Aging poses a global public health challenge, which is linked to the rise of age-related lung
diseases. The precise understanding of the molecular and genetic changes in the aging …

Progression to lung fibrosis in severe COVID-19 patients: A morphological and transcriptomic study in postmortem samples

B Pérez-Mies, T Caniego-Casas, T Bardi… - Frontiers in …, 2022 - frontiersin.org
The development of lung fibrosis is a major concern in patients recovered from severe
COVID-19 pneumonia. This study aimed to document the evolution of diffuse alveolar …

Identification and immunological characterization of cuproptosis-related molecular clusters in idiopathic pulmonary fibrosis disease

X Shi, Z Pan, W Cai, Y Zhang, J Duo, R Liu… - Frontiers in …, 2023 - frontiersin.org
Background Idiopathic pulmonary fibrosis (IPF) has attracted considerable attention
worldwide and is challenging to diagnose. Cuproptosis is a new form of cell death that …

The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis

MA Patel, DD Fraser, M Daley, G Cepinskas… - Molecular …, 2024 - Springer
Abstract Background The Multi-System Inflammatory Syndrome in Children (MIS-C) can
develop several weeks after SARS-CoV-2 infection and requires a distinct treatment …

Pathological mechanisms and novel drug targets in fibrotic interstitial lung disease

Y Nishioka, J Araya, Y Tanaka… - Inflammation and …, 2024 - Springer
Abstract Background Interstitial lung diseases (ILDs) are a diverse group of conditions
characterized by inflammation and fibrosis in the lung. In some patients with ILD, a …

First evidence of the protective effects of 2-pentadecyl-2-oxazoline (PEA-OXA) in In vitro models of acute lung injury

A Schiano Moriello, F Roviezzo, FA Iannotti, G Rea… - Biomolecules, 2022 - mdpi.com
Acute respiratory distress syndrome (ARDS) is a serious inflammatory lung disorder and a
complication of SARS-CoV-2 infection. In patients with severe SARS-CoV-2 infection, the …

Contemporary and emerging technologies for research in children's rare and interstitial lung disease

R Li, N Sone, S Gotoh, X Sun… - Pediatric …, 2024 - Wiley Online Library
Although recent decades have seen the identification, classification and discovery of the
genetic basis of many children's interstitial and rare lung disease (chILD) disorders, detailed …