Severe malaria: what's new on the pathogenesis front?
Plasmodium falciparum causes the most severe and fatal form of malaria in humans with
over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of …
over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of …
[HTML][HTML] Restraint-based three-dimensional modeling of genomes and genomic domains
Chromosomes are large polymer molecules composed of nucleotides. In some species,
such as humans, this polymer can sum up to meters long and still be properly folded within …
such as humans, this polymer can sum up to meters long and still be properly folded within …
A knockout screen of ApiAP2 genes reveals networks of interacting transcriptional regulators controlling the Plasmodium life cycle
K Modrzynska, C Pfander, L Chappell, L Yu, C Suarez… - Cell host & …, 2017 - cell.com
A family of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s)
was identified in malaria parasites. This family includes sequence-specific transcription …
was identified in malaria parasites. This family includes sequence-specific transcription …
A single-cell atlas of Plasmodium falciparum transmission through the mosquito
Malaria parasites have a complex life cycle featuring diverse developmental strategies, each
uniquely adapted to navigate specific host environments. Here we use single-cell …
uniquely adapted to navigate specific host environments. Here we use single-cell …
[HTML][HTML] Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth
MJ Chua, MSJ Arnold, W Xu, J Lancelot… - International Journal for …, 2017 - Elsevier
Malaria, schistosomiasis and leishmaniases are among the most prevalent tropical parasitic
diseases and each requires new innovative treatments. Targeting essential parasite …
diseases and each requires new innovative treatments. Targeting essential parasite …
Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development
Genome-wide analysis of transcription in the malaria parasite Plasmodium falciparum has
revealed robust variation in steady-state mRNA abundance throughout the 48-h …
revealed robust variation in steady-state mRNA abundance throughout the 48-h …
Epigenetic regulation of Plasmodium falciparum clonally variant gene expression during development in Anopheles gambiae
P. falciparum phenotypic plasticity is linked to the variant expression of clonal multigene
families such as the var genes. We have examined changes in transcription and histone …
families such as the var genes. We have examined changes in transcription and histone …
Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum …
Gene expression in Plasmodia integrates post-transcriptional regulation with epigenetic
marking of active genomic regions through histone post-translational modifications (PTMs) …
marking of active genomic regions through histone post-translational modifications (PTMs) …
Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum
XM Lu, G Batugedara, M Lee… - Nucleic acids …, 2017 - academic.oup.com
Gene expression in Plasmodium falciparum is tightly regulated to ensure successful
propagation of the parasite throughout its complex life cycle. The earliest transcriptomics …
propagation of the parasite throughout its complex life cycle. The earliest transcriptomics …
A comprehensive epigenome map of Plasmodium falciparum reveals unique mechanisms of transcriptional regulation and identifies H3K36me2 as a global mark of …
Background Role of epigenetic mechanisms towards regulation of the complex life
cycle/pathogenesis of Plasmodium falciparum, the causative agent of malaria, has been …
cycle/pathogenesis of Plasmodium falciparum, the causative agent of malaria, has been …